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When East meet West

Feipei Lai, Wei Chen, Chinjung Yang, Wei-Zen Sun, Li-Yan Sheen, Da-Cheng Su, Yin-Yi Han, Jia -Lin Hsu, Dun- Ren Tsai, Ping-Hong Kuo, Wei- Zhi Zhou S-Pulse Project Team, National Taiwan University 11/01/ 2013.

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When East meet West

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  1. Feipei Lai, Wei Chen, Chinjung Yang, Wei-Zen Sun, Li-Yan Sheen, Da-Cheng Su, Yin-Yi Han, Jia-Lin Hsu, Dun-Ren Tsai, Ping-Hong Kuo, Wei-Zhi Zhou S-Pulse Project Team, National Taiwan University 11/01/2013 – Opus One:how ICT and Big Data help reconcile Traditional Chinese Medicine with Science? WhenEastmeetWest

  2. Problem of Traditional Chinese Medicine (TCM) • Observation • Hypothesis • Experiment (Analysis, Simulation - Computing) • Theory/Model?

  3. Outline • Background • Goal • Approach • Latest Programs and Results • Conclusion • Future work

  4. When East meet West East West

  5. Basic Concept of Traditional Chinese Medicine Holism: the unity and integration of the whole body整體論

  6. The Harmonization between the Natural World and the Human Being 天人合一

  7. The Most Basic Element of Traditional Chinese Medicine: Qi • Air • Life force • The flow of energy, goes around and through the body, pushes the blood. • Resonance? • Electric Current? • EMW?

  8. Qi pushes the blood. Feeling Qi through the pulse.

  9. Radial Artery Pulse: the Window to Measure Qi Pulse Diagnosis Device (sphygmograph)

  10. Outline • Background • Goal • Approach • Latest Programs and Results • Conclusion • Future work

  11. Integrating Traditional Chinese Medicine into Mainstream Medicine by Bioinformatics Traditional Chinese Medicine Mainstream Medicine Bioinformatics

  12. Goal With modern bio-informatics and large volume of pulse data, the linkage between Traditional Chinese Medicine and Mainstream Medicine should be probed. A cloud-based platform for diseases classification based on pulse data should be developed.

  13. Outline • Background • Goal • Approach • Latest Programs and Results • Conclusion • Future work

  14. Pulse Analysis

  15. Analysis of Arterial Pulse Wave M. G. Taylor: An Approach to an Analysis of the Arterial Pulse Wave (1957) “Harmonic may have something to do with organs"

  16. Related Work WK Wang: Harmonic Theory of pulse wave 心=Heart 肝=Liver 腎=Kidney 脾=Spleen 肺=Lung 胃=Stomach 膽=Gallbladder 膀胱=Bladder 大腸=Large Intestine 三焦=Sanjiao小腸=Small Intestine

  17. Harmonic Theory of Pulse wave Base on the length from heart to the specific organ and the blood vessel structure, harmonic is formed to deliver blood to each organ efficiently. (The length of vertical blood vessel from aorta to the specific organ) 心=Heart 肝=Liver 腎=Kidney 脾= Spleen 肺=Lung 胃=Stomach 膽=Gallbladder 膀胱=Bladder

  18. Cloud-Based S-Pulse Platform

  19. FFT Analysis Platform

  20. Uploaded Pulse Data Management

  21. Outline • Background • Goal • Approach • Latest Programs and Results • Conclusion • Future work

  22. Latest Programs and Results • Dr. T-C Su • Different age groups • Cardiovascular • Dr. J-L Hsu • CMV Mode vs. CPAP Mode • Dr. Y-Y Han • Hospice Patients • Liver transplantation Patient • Dr. P-H Kuo • Asthma, COPD • Prof. L-Y Sheen • Ginger Tea, Coconut juice and Water

  23. Dr. T-C Su Age Cardiovascular - OGTT_DM (Oral Glucose Tolerance Test) - Hypertension - Metabolic Syndrome

  24. Different Age Groups

  25. Different Age Groups OKfragments rate: 0.776389

  26. Different Age Groups OKfragments rate: 0.776389 Fragment selection + LOG

  27. Different Age Groups - Discussion • High frequency harmonic waves become smaller in elderly people. • Coherent to Prof. Wang’s research. • High frequency harmonic waves occur based on the reflection of blood vessels. While the vessels get stiffer, the harmonic waves become smaller.

  28. Different Age Groups OKfragments rate: 0.776389 Harmonic - Ratio

  29. Different Age Groups OKfragments rate: 0.776389 Harmonic Log - Ratio

  30. Oral Glucose Tolerance Test (OGTT) • Fasting for 8 hours • Drink glucose water (75g glucose in 250-300mL water) • Check blood glucose 2 hours later • Normal < 140 mg/dLImpaired glucose tolerance 140-199 mg/dLDiabetes Mellitus ≥ 200 mg/dL dL = 100cc

  31. OGTT_DM vs. Control

  32. OGTT_DM vs. Control OKfragments rate: 0.833924

  33. OGTT_DM vs. Control OKfragments rate: 0.833924

  34. OGTT_DM vs. Control OKfragments rate: 0.833924 Harmonic - Ratio

  35. OGTT_DM vs. Control OKfragments rate: 0.833924 Harmonic Log - Ratio

  36. Hypertension vs. Control

  37. Hypertension vs. Control OKfragments rate: 0.841426

  38. Hypertension vs. Control OKfragments rate: 0.841426

  39. Hypertension vs. Control OKfragments rate: 0.841426 Harmonic - Ratio

  40. Hypertension vs. Control OKfragments rate: 0.841426 Harmonic Log - Ratio

  41. Metabolic Syndrome 3 out of 5 criteria • Central obesity: waist circumference male ≧ 90 cm, female ≧ 80 cm • Hypertension: SBP ≧ 130 mm-Hg, DBP ≧ 85 mm-Hg • Raised fasting glucose ≧ 100 mg/dL • Dyslipidemia HDL-C male < 40mg/dL, female < 50mg/dL • Raised Triglyceride (TG) ≧ 150mg/dL

  42. Metabolic Syndrome vs. Control

  43. Metabolic Syndrome vs. Control OKfragments rate: 0.850194

  44. Metabolic Syndrome vs. Control OKfragments rate: 0.850194

  45. Metabolic Syndrome vs. Control OKfragments rate: 0.850194 Harmonic - Ratio

  46. Metabolic Syndrome vs. Control OKfragments rate: 0.850194 Harmonic Log - Ratio

  47. Dr. J-L Hsu • CMV mode (Continuous Mandatory Ventilation): Restricted AIR mode, Constrain Breath Time • CPAP mode (Continuous Positive Airway Pressure) : Not so restrict AIR mode, Help patient with their breathing

  48. CMV vs. CPAP

  49. CMV vs. CPAP OKfragments rate: 0.571051

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