Histone Demethylation Pathway

1. Histone Demethylation Pathway Histone methylation modification is a reversible dynamic regulation process. Methylation and/or demethylation status is closely related to epigenetics, transcriptional regulation, and maintenance of genomic integrity. Abnormalities in histone methylation status directly or indirectly affect various physiological and pathological processes. Histone demethylases lysine-specific demethylase (LSD) family and the JMJD family containing the Jmj C domain. The study found that both have a close relationship with the occurrence of tumors. Therefore, the treatment of cancer with histone demethylation as a target has become a hot research topic. are known to include the Histone demethylation family Unlike the dynamically regulated acetylation and phosphorylation processes, histone methylation modifications have been considered irreversible for a long time. Until 2004, Professor Shi discovered the histone lysine-specific demethylase (LSD1) for the first time. The demethylase LSD1 first binds to the histone tail lysine methylation site. The substrate was catalyzed to remove the methyl group at the tail of histones, confirming the presence of demethylase, and confirming that methylation and demethylation of histones is also a dynamic regulation process. Find more at: https://www.creative-diagnostics.com/histone-demethylation-pathway.htm