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nf kb signaling

NF-kB is a short name of Nuclear Factor kappa-light-chain-enhancer of activated B cells. It is not a single protein, but a small family of inducible transcription factors that play an important role in almost all mammalian cells.

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nf kb signaling

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  1. nf kb signaling What is NF-kB? NF-kB is a short name of Nuclear Factor kappa-light-chain-enhancer of activated B cells. It is not a single protein, but a small family of inducible transcription factors that play an important role in almost all mammalian cells. It control DNA transcription, cytokine production, cell survival and other important cell events, especially play a key role in regulating the immune response to infection. NF-kB molecular are usually dimers. A typical structure of NF-kB is P50-P65 dimer (NF-kB1/RelA). The dimer formation is necessary for DNA binding, two NF-κB monomers bind to DNA as a dimer. The N-terminal regions of dimer are responsible for specific DNA contact. The C-terminal regions are usually highly conserved, they are responsible for dimerization and nonspecific DNA phosphate contact. The whole NF-kB molecular is just like a pliers vise on the DNA chain and function as a transcription factor (figure 2). http://www.creative-diagnostics.com/The-NF-kB-Signaling-Pathway.htm

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