CM-Path Network Development

1. CM-Path Network Development +

2. What is CM-Path? • Severe decline in the number of clinical academic pathologists over the past 15 years compared with other clinical academic specialties • Increasing need for molecular testing within the NHS • - New technologies • - New skills required • - Pathology capacity • Disconnect between pathology research, clinical practice and industry

3. Salto-Tellez M. Clinical Chemistry 2007 Jul;53(7):1188-90 Anatomical clinical-molecular dimension of pathology Molecular Pathology (Molecular Diagnostics) Clinical Medicine Traditional Pathology The future of modern medicine will be dictated by technical advancement, management advancements, and advancements in molecular medicine – stratified medicine 2. Molecular Diagnostics in the fastest growing area in modern medicine

4. Changing the way we analyse human tissues • Next Generation Sequencing – DNA, RNA • Targeted gene panels • Methylation analysis • Multiplexed analysis • Digital pathology and artificial intelligence

5. Changing the way we handle human tissues • Optimal fixation for immunohistochemistry • Routine handling of fresh tissue • Optimal tissue selection for molecular analysis • Better regional/ national standardisation • Biobanking– a focus on tissue quality, access & consent • Engagement with industrial partners

6. Transformative NHS projects - 100,000 Genomes Project • Handling the tissues • WGS - formalin fragments the DNA • Eliminating formalin from theatres • Small diagnostic biopsies best in 10% NBF • Training staff to sample fresh tissue • Fresh tissue can be stored at 4oC for ? * • Maintenance at 4oC during transport • Recording time of removal and arrival • Transformational project • Rare genetic diseases • Cancer samples • Fresh samples 5 x 5 x 5mm • Cellularity score (EQA) • Consent by Genomic staff • HRA/HTA statement April 2017 * Currently under discussion

7. What is CM-Path? Karin Oien (Chair), Andy Hall (Deputy Chair) Input from trial designers and funders Input from patients and public CM-Path Executive Group Skills and capacity Clinical trials Discovery Technology and information Clare Verrill Gareth Thomas AbeerShaaban Louise Jones Cross-cutting themes Biosample Consent Engaging with wider initiatives Supporting Trainees Patient and Public Engagement

8. CM-Path Vision: Working Together Pathology research across NHS, academia and industry Supporting clinical trials and tissue-based research Coordinating new approaches to diagnosis

9. CM-Path Vision: Working Together CRUK Accelerators CRUK Strat Med CCB/UKCRC NC3R Academic training Molecular pathology MRC Nodes CM-Path Biobanking Technology & innovation Clinical Trials RCPath Sanger Institute Biomarker Research NCRI CSGs PathSoc Genomics England

10. CM-Path Network Network • The ambition: • A UK-wide network of CM-Path ‘badged’ pathology centres • The purpose/objectives: • Support pathology centres to engage in research-based activities: biobanking, clinical trials, tissue-based research • Support clinical & academic training and development: RCPath curriculum, workshops, clinical trials, new technologies, funding, • Help establish UK-wide best practice for molecular testing across the UK: Tissue handling, processing, analysis • CM-Path Network Requirements • Named CM-Path clinical and laboratory representative in each department

11. What will you get for signing up to the CM-Path Network? • Training: across all stages of career; workshops, courses & online modules • Clinical Trials: training, analysis, costing, tissue release • Time: funding research time, job plans, grant opportunities, • Tests & Technologies: digital pathology, sequencing technologies • Tissue: consent, access, handling, processing, biobanking, SOPs • Opportunities for research: pathologists directory, collaborations • Molecular testing: advice, download SOPs • Quarterly newsletter: linking you to CM-Path activity, opinion pieces, workshops, training, opportunities to input into calls for information

12. CM-Pathologists (The Pathology Directory) Network • I'm a pathologist, what will I get out of being on the directory • Tell us your name, email, area of interest, what you might be interested in getting involved in an we can match you up to various opportunities/you may be contacted by various people to get involved with projects or scientific review committees • Easily link up with fellow pathologists interested in research or trainees looking for projects to get involved in • I'm a research funding organisation what will I get out of using the directory: • CM-Path encourages funding organisations that award research grants to incorporate a pathology review • The pathology directory will help you to identify pathologists across the country that might be interested in joining a funding committee. You will be able to see their speciality and any previous experience they might have • I'm part of an industrial organisation or a researcher what will I get out of using the directory: • Want to involve a pathologist in your work or need help developing a research proposal, use the directory to more easily link yourself up to pathologists who want to be involved in research.

13. The Alternative https://goo.gl/images/wh434K https://goo.gl/images/bRlhmX

14. Find out more about what CM-Path is doing… cmpath.ncri.org.uk Email cmpath@ncri.org.uk for… Pathology collaborations Pathology advice Further information