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Molecular Phylogenetics

Molecular Phylogenetics

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Molecular Phylogenetics

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  1. Molecular Phylogenetics The Tree of life image that appeared in Darwin’s On the Origin of Species by Natural Selection, 1859. This is the only figure in On the Origin of Species.

  2. DNA Mutation • A change in the nucleotide sequence of the genetic material of an organism • Create variation in the gene pool upon which natural selection can act • Only germ line mutations can be passed on to descendants

  3. Causes of DNA Mutations • Replication errors • Chemical mutagens • Ionizing Radiation • UV Radiation

  4. Types of DNA Mutations www.intelihealth.com

  5. Types of Mutations Deletion Insertion Do you think point mutations or insertions/deletions have greater effects? www.intelihealth.com

  6. Mutation Rates • Eukaryotes: 10-4 to 10-6 mutations per base pair per generation • Bacteria: 10-8 mutations per base pair per generation • Human genome size: 3 billion base pairs • Bacteria: 0.5-10 million base pairs Do you think most mutations are harmful? Beneficial?