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PRIMARY

THE DISEASE Raising Incidence : 6000 nc / yr , 1500 dead/ yr Younger patients !!. A PREVENTABLE DISEASE !!! . IMPROVED Prevention and Early Diagnosis reduced Mortality Rate with Screening Programs ( J. Invest . Dermatol 132:1311.2012). Prognosis. METASTATIC .

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PRIMARY

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  1. THE DISEASE RaisingIncidence: 6000 nc/yr , 1500 dead/yrYoungerpatients !! A PREVENTABLE DISEASE !!! IMPROVED Prevention and EarlyDiagnosis reducedMortality Rate with Screening Programs ( J. Invest. Dermatol 132:1311.2012) Prognosis METASTATIC PRIMARY High Cure Rates UntilRecently……

  2. The Biology VGP RGP MolecularCharacterizationofTumorProgression B E F D MotilityInvasion Growth C Loss of keratinocytes control Angiogenesis Fibroblasts ECM ECM

  3. TranslationalRelevance Table 3. Antigenic Phenotype of ABCG+ IGR37 melanoma xenograft DifferentiationAgsProgressionAgsCancertestisAgs HMW-MAA positive CD9 positive NY-ESO-1 negative HBM-45 positive c-met positive MAGE-A positive Melan-A positive HER-3 positive ET-Br positive Tenascinpositive ET-1 negative PlosOneDec,2010 Imaging Gene Array S L N “Stem” Cells Smallmolecules target therapy Immuno-therapy Agonistic and AntagonistRecepotrs

  4. Table 3. Antigenic Phenotype of ABCG+ IGR37 melanoma xenograft Differentiation Antigens Progression antigens Cancertestis antigens HMW-MAA positive CD9 positive NY-ESO-1 negative HBM-45 positive c-met positive MAGE-A positive Melan-A positive HER-3 positive ET-Br positive Tenascinpositive ET-1 negative PlosOneDec,2010

  5. THE DISEASE Incidence: 6000 nc/yr , 1500 dead/yr Prognosis METASTATIC PRIMARY Resistant…….. toavailabletherapies IMPROVED Prevention and EarlyDiagnosis High Cure Rates A PREVENTABLE DISEASE !!!

  6. THE DISEASE Incidence: 6000 nc/yr , 1500 dead/yr IMPROVED Prevention and EarlyDiagnosis A PREVENTABLE DISEASE !!!

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