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Nanotechnology ; new materials new risks

Nanotechnology ; new materials new risks

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Nanotechnology ; new materials new risks

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  1. Nanotechnology;new materialsnew risks Workshop on Emergingcontaminants in European waters Anne Thoustrup Saber (ats@nrcwe.dk), Håkan Wallin and Ulla Vogel

  2. National Research Centre for the Working Environment A strategic focus on health risk related nanotoxicology was initiated at NRCWE in 2005: 22 man-years annualy

  3. Why ? • Increasinguse of nanomaterials • Nanomaterialtoxicitydiffersfrom bulk chemicals • Knowledge on the mechanisms of nanomaterial toxicity will make it easier to take the appropriate precautions in the working environment and the rest of the society

  4. The toxicology of nanomaterials Risk of highereksposure: Nanomaterials Nanomaterials in a matrix Deposition deep down in the lung and slow clearence Systemictranslocation of nanomaterials Health effects of inhalation: Inflammation Cardiovasculardisease Cancer Acutelungtoxicity

  5. Special concern:Carbonnanotubes (CNTs) • CNTs have a number of unique and attractivecharacteristics: • 10-100 times strongerthansteel but much lighter, to beused as enforcement of compositmaterials • High electronic and heat conductionmakingthemattractive as electric components

  6. Carbonnanotubes: the flipside of the coin • Long, thin, respirable fibres • Chemically resistent • Induce long lasting inflammation • produce ROS, reactiveoxygen species • Asbestos-like?

  7. Nanomaterials embedded in a matrix ?

  8. Very limited data on the toxic effects of nanomaterials embedded in different matrices and of dust generated by sanding of nanomaterial-containing products • Rat instillationstudy: • Cement (CEM) • Thermoplastic (POM) • NPs • Mouse instillationstudy: • Paints • Lacquers • NPs } } +/- NP +/- NP (Wohlleben et al., Small, 2011) (Saber et al., Nanotoxicology, 2011 a,b)

  9. Very limited data on the toxic effects of nanomaterials embedded in different matrices and of dust generated by sanding of nanomaterial-containing products • Rat instillationstudy: • Cement (CEM) • Thermoplastic (POM) • NPs • Mouse instillationstudy: • Paints • Lacquers • NPs } } +/- NP +/- NP The hazardscould not bedistinguished for sandingdusts with or withoutnanoparticles Effectsarelower for particlesencapsulated in a matrix than the pure nanoparticles (Wohlleben et al., Small, 2011) (Saber et al., Nanotoxicology, 2011 a,b)

  10. Can thesepreliminaryconclusionsbegeneralized to othernanomaterialcontainingcomposites?

  11. Can thesepreliminaryconclusionsbegeneralized to othernanomaterialcontainingcomposites? New European projectNanoSustain (2010-2013) : • Test of NPs and products with and withoutNPs: • Paintedboards(+/- nanoTiO2) • Epoxy plates (+/- CNT) • Coatedglasssheets(+/-nanoZnO) • Paper (+/-nanocellulose) • How, and to what degree, will the environment be exposed to nanomaterialsand associated products • 2.Where do these particles end up? Release into water? Effects of weathering? Emission from waste incineration? • 3. What are the toxicological effects?

  12. Thankyou for your attention!