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A novel model for blood impedance for indirect viscosity measurement

A novel model for blood impedance for indirect viscosity measurement. Zu-yao Chang, Gerard C.M. Meijer and Gheorghe A.M. Pop Faculty of Electrical Engineering, Mathematics and Computer Science,.  Soz 2004. Structure. Introduction Contents of Blood Measurement techniques Measurement setup

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A novel model for blood impedance for indirect viscosity measurement

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  1. A novel model for blood impedance for indirect viscosity measurement Zu-yao Chang, Gerard C.M. Meijer and Gheorghe A.M. Pop Faculty of Electrical Engineering, Mathematics and Computer Science,  Soz 2004.

  2. Structure • Introduction • Contents of Blood • Measurement techniques • Measurement setup • Experimental results • Conventional Model • Novel Model • Conclusions  Soz 2004.

  3. Source: Centraal Bureau voor de Statistiek Introduction • Heart and arterial diseases death cause no 1.

  4. Introduction • Higher viscosity  higher risk of blood-clot forming • Good correlation between blood viscosity and blood impedance.  Soz 2004.

  5. Introduction  Soz 2004.

  6. Contents of Blood • Plasma (volume 55%) • Blood Cells (volume 45%) • Leukocytes (white blood cells) • Thrombocytes (platelets) • Erythrocytes (red blood cells)  Soz 2004.

  7. Zpol Measurement technique • Two-electrode measurement technique • Four-electrode measurement technique  Soz 2004.

  8. HP4192A Vosc LabVIEW measurement circuit GainPhaseanalyzer Measurementcell Measurement circuit measurement cell GainG, Phase  Impedance of Blood Mathematicalcalculations Labview |Z|,  Measurement setup(4-electrodes)  Z.Chang, 2003.

  9. Nyquist Plot Polarization effects Blood Dielectric Properties of water Ht=45% T=24C Experimental results  Soz 2004.

  10. Conventional Model • Resistor Rp: plasma resistance with non-conducting blood cells. Rp • Capacitor Cm: cell-membrane capacitance. Ri Cm • Resistor Ri: interior cell-resistance. Where is the dielectric capacitance of water ?  Soz 2004.

  11. Nyquist plot of four-electrodes measurement Blood, Ht=45%, T=24ºC conv. model <1.2 MHz conventional model full freq. range Conventional Model  Soz 2004.

  12. Nyquist plot of two-electrodes measurement Cliq Blood, Ht=45%, T=24ºC Improved model total freq. fit Conventional Model  Soz 2004.

  13. Resistor Rp: plasma resistance with non-conducting blood cells. Cliq • Constant-Phase element CCPE_m: cell-membrane capacitance. Rp Ri CCPE_m Novel Model • Resistor Ri: interior cell-resistance. • CapacitorCliq: dielectric capacitance.  Soz 2004.

  14. Nyquist plot of four-electrodes measurement novel model Blood, Ht=45%, T=24ºC Conv. model, 3pnt Conventional model, all Novel Model  Soz 2004.

  15. Nyquist plot of two-electrodes measurement novel model Blood, Ht=45%, T=24ºC Conventional model with Cliq Novel Model  Soz 2004.

  16. Conclusions • It is possible to predict blood viscosity via blood impedance. • The validity of the early model of blood impedance is limited. • A novel model of blood impedance is found and its validity verified until 100MHz.  Soz 2004.

  17. Questions ?  Soz 2004.

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