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The Promise of Stem Cell Research

The Promise of Stem Cell Research. Immunogenicity Characterization of UCBMNCs. Stem Cell-derived 3 D Skin Model. Defg1/Dcph1. SC5314. Defg1. Dcph1. BLM Cells infiltrate the Dermis. M13 Cells build Tumor Nests. SK Mel 28 Cells. Microbiology 2002;148:497-506. Stem Cell-derived Liver Model.

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The Promise of Stem Cell Research

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  1. The Promise of Stem Cell Research

  2. Immunogenicity Characterization of UCBMNCs

  3. Stem Cell-derived 3 D Skin Model Defg1/Dcph1 SC5314 Defg1 Dcph1 BLM Cells infiltrate the Dermis M13 Cells build Tumor Nests SK Mel 28 Cells Microbiology 2002;148:497-506

  4. Stem Cell-derived Liver Model MIT researchers have devised a novel way to create tiny colonies of living human liver cells that model the full-sized organ. The work could allow better screening of new drugs that are potentially harmful to the liver and reduce the costs associated with their development.

  5. Stem Cell-derived Cardiac Model • A host of fluorescent imaging techniques allow easy and accurate measurement of such important physiological parameters as mitochondrial membrane potential and reactive oxygen species production and cytoplasmic ion concentrations in engineered tissue 3D confocal rendering of an engineered cardiac tissue, demonstrating the ability to visualize with great resolution the structures within an engineered tissue construct.

  6. Stem Cell-derived Bronchial Model

  7. 3D Model of Various Organs

  8. Cancer Stem Cells  Potential Cancer Models with Possible Reverting/Inhibiting Mechanisms • Problems : • So many different types of CSCs with unidentified tons of CSCs markers • Reverting/Inhibiting system should be “Personalized therapy”

  9. Somatic Cell Nuclear Transfer (SCNT) & Induced Pluripotent Stem Cell (iPS) • TIME LINE OF iPS RESEARCH • 2006 1st Generated from mice fibroblast by Takahashi & Yamanaka (Cell 2006;126:1-14) • 2007 Generated from adult human fibroblast cells by Yamanaka et. al (Cell 2007;131:861-72)  using Oct3/4, Sox2, c-Myc, Klf4 • 2007 Generated from postnatal human fibroblast cells by Thomson et. al (Scienceexpress 2007; 10.1126/science.1151526)  using Oct4, Sox2, Nanog, Lin28

  10. iPS to Mouse Embryonic Development Contribution of mouse iPS to mouse embryonic development  chimaera mouse Takahashi & Yamanaka (Cell 2006;126:1-14)

  11. Associations for Stem Cell Research International: International Society for Stem Cell Research http://www.isscr.org ISSCR International Society for Cellular Therapy http://www.celltherapysociety.org Indonesia: Asosiasi Sel Punca Indonesia (ASPI) Indonesian Stem Cell Association !! Join for free, contact: ferrysandra@yahoo.com

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