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This study examines the impact of Gwennpaullone and Ethanolamine on rat tissues and the CCL39 cell line, focusing on GSK-3 isoforms, Erk1, Erk2, and CDK5. The analysis explores molecular interactions and signaling pathways through various proteins.
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Porcine brain A Gwennpaullone Ethanolamine C3-paullone Purvalanol Axin kDa 97.4- GSK-3 66.2- GSK-3 Erk1 Erk2 45.0- MDH (1) CDK5 31.0- p25 21.5- GSK-3 B GSK-3 MDH CDK5 C D Figure 2 Knockaert et al.
Rat tissues Spleen Muscle Brain Heart Liver Lung kDa 97.4- 66.2- 45.0- 31.0- 21.5- GSK-3 GSK-3 MDH A B C Figure 5 Knockaert et al.
Gwennpaullone Gwennpaullone Ethanolamine Ethanolamine CCL39 cell line kDa -97.4 -66.2 GSK-3 GSK-3 GSK-3 GSK-3 MDH (2) -45.0 -31.0 -21.5 Figure 6 Knockaert et al.
Xenopus oocytes Gwennpaullone Ethanolamine kDa 97.4- MDH (3) 66.2- 45.0- 31.0- 21.5- Figure 7 Knockaert et al.