40 likes | 156 Vues
Study on the molecular interaction between Exon 2 and Exon 14 in immune response genes. Investigates gene loci, fold changes, and protein products.
E N D
23 Kb Exon 2 Exon 14 Exon 1 cc cgacaaacacg gtcg cagaaac FP1 2R For Rev f1 ATG Exon 14 Exon 1 Exon 2 f17 PGA2 Unt. f1 f17 Actin 1 2 Time (h) 24 12 6 16 0 f1 f17 Actin A B C Pavithra et al., Figure S1
A B - PGA2 + PGA2 - PGA2 + PGA2 Immune Immune Input Input Pre Pre Immune Immune Input Input Pre Pre IB: a-HDAC1 IB: a-HDAC1 IB: a-SMAR1 IB: a-SMAR1 IP: a-SMAR1 IP: a-HDAC1 Pavithra et al., Figure S2
PGA2 (mM) A Unt. 30 70 70 Cyc D1 SMAR1 b- actin siRNA Scr. B Scr. + + Si-RNA PGA2 (mM) 30 70 30 70 70 Cyc A Cyc B Cdk2 Cdk6 b-actin 1 2 3 4 5 6 Pavithra et al., Figure S3
PGA2VsPGA2 + siRNA Cells vs SMAR1 A B Code Gene Locus Fold change Products A B Pavithra et al., Figure S4