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Case Report on Dedifferentiation of Adenoid Cystic Carcinoma Implicating p53 Mutation

This report details a unique case of dedifferentiation in adenoid cystic carcinoma associated with a mutation in the p53 gene. Notably, the study indicates significant findings related to tumor behavior and potential therapeutic targets. Additionally, it discusses the role of genetic factors, such as CYP1A1 genotype in lung cancer risk, ACE-D allele effects on ventricular arrhythmias, and findings from a retrospective analysis of medulloblastomas. This case contributes to the understanding of gene-disease interactions in oncology.

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Case Report on Dedifferentiation of Adenoid Cystic Carcinoma Implicating p53 Mutation

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  1. Feature Set

  2. ARG2 gene/disease X Feature 2 • Dedifferentiation of adenoid cystic carcinoma: report of a case implicatingp53 gene mutation.

  3. ARG1 ARG2 X Y gene/disease Feature 3 • (negative example) We have assessed the role of CYP1A1 genotype in lung cancer risk in the Chinese population via a case-control study.

  4. ARG1 ARG2 X gene/disease Y Feature 4 • The ACE-D allele had additive and dominant effects with regard to the occurrence of significant ventricular arrhythmias after adjusting for other risk factors. • RESULTS: Only the three medulloblastomas with T antigen expression also showed nuclear positivity with antibodies to p53.

  5. Feature 5 • These results suggested that targeted disruption of Cyp19causedanovulation and precocious depletion of ovarian follicles. • Furthermore, AML cells with methylated p15(INAK4B) tended to express higher levels of DNMT1 and 3B. ARG1 ARG2 disease/gene gene/disease X

  6. Feature 7 ARG1 MOD ARG1 • Mutations in the EYA1 gene (localised to 8q13.3) account for nearly 70% of BOR syndrome cases exhibiting at least three of the major features. • We have shown previously that adenoviral-mediated E2F-1 over expression induces efficient apoptosis incolonadenocarcinoma cells. gene/disease X Y disease/gene

  7. Results • results for the test set

  8. Extraction Results

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