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F 2006 BIOC 3405

F 2006 BIOC 3405. 11-16-06. Nucleotides. Nucleoside phosphate Base and ribose (or deoxyribose) Pyrimidine Purine. Minor Bases. Nomenclature Substituent on ring Substituent on N on ring. Reason for instability of RNA. Bases. Slightly basic Highly conjugated UV absorbers

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F 2006 BIOC 3405

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  1. F 2006 BIOC 3405 11-16-06

  2. Nucleotides • Nucleoside phosphate • Base and ribose (or deoxyribose) • Pyrimidine • Purine

  3. Minor Bases • Nomenclature • Substituent on ring • Substituent on N on ring

  4. Reason for instability of RNA

  5. Bases • Slightly basic • Highly conjugated • UV absorbers • Nearly flat (Purines slightly out of plane) • Insoluble at normal pH • Hydrophobic stacking minimizes interaction with water • Capable of H-bond formations in complementary ways

  6. Schreiner U, 1977-1990

  7. Chargaff’s Rules • DNA from different species have different base compositions • DNA from same species (or tissues from same individual) have the same composition • Base composition constant over time, environmental conditions, state of organism • A=T and G=C

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