1 / 80

Understanding Nucleotides: Structure, Stability, and Chargaff’s Rules in DNA

Explore the essential components of nucleotides: nucleoside phosphates, bases, and ribose or deoxyribose structures. Dive into the characteristics of purines and pyrimidines, and their minor bases, focusing on the stability and molecular interactions of RNA bases. Learn about Chargaff's rules that govern base composition variability among species and the consistency observed in individual organisms. This comprehensive overview will enhance your understanding of biochemical nucleotides, their nomenclature, and the critical roles they play in genetics.

verlee
Télécharger la présentation

Understanding Nucleotides: Structure, Stability, and Chargaff’s Rules in DNA

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. F 2006 BIOC 3405 11-16-06

  2. Nucleotides • Nucleoside phosphate • Base and ribose (or deoxyribose) • Pyrimidine • Purine

  3. Minor Bases • Nomenclature • Substituent on ring • Substituent on N on ring

  4. Reason for instability of RNA

  5. Bases • Slightly basic • Highly conjugated • UV absorbers • Nearly flat (Purines slightly out of plane) • Insoluble at normal pH • Hydrophobic stacking minimizes interaction with water • Capable of H-bond formations in complementary ways

  6. Schreiner U, 1977-1990

  7. Chargaff’s Rules • DNA from different species have different base compositions • DNA from same species (or tissues from same individual) have the same composition • Base composition constant over time, environmental conditions, state of organism • A=T and G=C

More Related