NanoSiTec: Nanoparticle coating for inhibition of biofilms

1. SiO SiO SiO SiO SiO SiO SiO 2 2 2 2 2 + + + + + + + + + + + + + + NanoSiTec: Nanoparticle coating for inhibition of biofilms • Problem/Need • There is an increasing need to address microbial growth in end application markets such as healthcare, medical devices and consumer products. • Furthermore this will need to be achieved without increasing the build up of resistant micro-organisms, i.e. the development of non biocidal products. Cells on the untreated surface do not spread onto the treated surface Opportunity The NanoSiTec product is based on a simple and cost-effective nanoparticle silica coating, which inhibits the adhesion and therefore proliferation of cells and micro-organisms thus preventing the formation of biofilms. The technology has a mass market appeal as it is effective without the need for intervention using hazardous biocidal chemicals. • Technology • The technology exploits the principle that the chemical-physical properties and topography of surfaces have a major impact on cell behaviour i.e. adhesion, proliferation and orientation and on the ability of cells and organisms to adhere to a substrate. • By deposition of amorphous-colloidal-silica of defined particle size, using a simple coating process an efficient anti-adhesive substrate can be achieved. • The one step coating can be easily applied through dipping, wiping or spraying. 2 2

2. USP/Competitive Advantage • Easily manufactured – via a simple mixing step • Versatile - can be applied to most surfaces and shapes • Cost-effective - readily available raw materials • Environmentally friendly - no need to use hazardous chemicals • Stable – the product has an extensive shelf life and does not deteriorate over time • Non-toxic - alternative to biocide • Intellectual Property • International Patent. WO 02101028, June 2002, (Granted in US). Route forward The technology is a platform based core technology. The exploitation plan is based on securing targeted licences across market sectors or sale of the technology. • Technology development • Demonstrated the cell response with a range of cell types (mammalian, fungal and bacterial) • Coated a wide range of materials producing stable coatings of silica nanoparticles • Not limited by complex geometries • Demonstrated that the coating can significantly reduce the growth of Candida albicans biofilms. Candida albicans is the common fungal infection that causes oral thrush. Markets This platform technology has multiple potential applications in both medical and non medical applications. • Available information • Non confidential data pack • Patent Specifications • Sample coating Contact: Dr Gillian Murray Ulive Enterprises Ltd. T +44 (0) 151 705 3699 E gillian.murray@ulive-enterprises.com www.ulive-enterprises.com