SlideServe
Télécharger Obtenir Pro
Menu
Accueil Pro
Préférences
ApparenceLight Aide et commentaires
© SlideServe · v2026

Clopidogrel and Aspirin vs. Aspirin Alone for Atherothrombotic Event Prevention

vondra avatar
vondra
8 diapositives · 232 Views · Sep 05, 2014

This review evaluates the efficacy and safety of Clopidogrel combined with Aspirin versus Aspirin alone in preventing cardiovascular events. Conducted through a multicenter, randomized, double-blind clinical trial involving over 15,000 participants, the study assessed cardiovascular risks, including myocardial infarction, stroke, and mortality. Results indicated a significant increase in moderate bleeding events with dual therapy but a potential reduction in overall cardiovascular events. The findings highlight the necessity for pharmacists to evaluate dual therapy prescriptions and assess appropriateness based on patient history and guidelines.

Clopidogrel and Aspirin vs. Aspirin Alone for Atherothrombotic Event Prevention - slide 1
01 / 8Clopidogrel and Aspirin vs. Aspirin Alone for Atherothrombotic Event Prevention
1 / 17

Télécharger la présentation

Clopidogrel and Aspirin vs. Aspirin Alone for Atherothrombotic Event Prevention
Une image / un lien ci-dessous est fourni (tel quel) pour télécharger la présentation

Politique de téléchargement : le contenu du site vous est fourni TEL QUEL pour votre information et votre usage personnel ; il ne peut être vendu, concédé sous licence ni partagé sur d’autres sites sans l’accord de son auteur.Le contenu vous est fourni TEL QUEL, pour votre information et votre usage personnel uniquement. Téléchargez la présentation en cliquant sur ce lien. Lors du téléchargement, si vous ne parvenez pas à télécharger une présentation, l’éditeur a peut-être supprimé le fichier de son serveur.Pendant le téléchargement, si vous ne parvenez pas à obtenir une présentation, le fichier a peut-être été supprimé par l’éditeur.

F I N

Plus de contenu associé

Transcription de la présentation

  1. A Review of –Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events Ted Williams Pharm D Candidate Monday Lab – Group D

  2. Clopidogrel & Aspirin - When should pharmacist intervene? • Joe, 47 yo male Diabetic • Betty, 68 yo female with a hx of Angina • Phil, 76 yo male 2 yrs post-PCI • Jean, 57 yo female hospital discharge orders for Clopidogrel, ASA, Metoprolol Succinate, Lisinopril, Lipitor, Nitroglycerin SL, oxycodone, Hydrocodone/APAP

  3. Study Objective • Determine if Clopidogrel + ASA 81mg decreases risk of CV Events vs. ASA 81mg alone.

  4. Methods – for completeness • Study Design • Multicenter, randomized, double-blind, placebo-controlled (n=15,603) • Executed by Cleveland Clinic Cardiovascular Coordination Center • Sponsored by Sanofi-Aventis & Bristol-Myers (Plavix Patent holder) • Plavix + ASA 81mg vs. Placebo + ASA 81mg • Inclusions • >45yrs • Established CVD • Multiple risk factors for CVD • Efficacy • Primary end point of MI, Stroke, or Death due to CV event/hemorrhage • Secondary endpoint incidence of CV events or hospitalization for CAD related events • Safety • Pearson chi-square test

  5. Efficacy Findings Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events. (NEJM 2007;354:1706-17)

  6. Safety Findings • Moderate Bleeding significantly increased • GUSTO Moderate: bleeding that led to transfusion, but did not meet “severe” criteria Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events. (NEJM 2007;354:1706-17)

  7. Clopidogrel & Aspirin –When should pharmacists intervene? • Joe, 47 yo male diabetic • Diabetics should be on ASA 81mg (ADA) • Any Clopidogrel prescription should raise a question • Betty, 68 yo female with a hx of Angina • Dual therapy not indicated • Investigate with patient & MD • Phil, 76 yo male 2 yrs post-PCI • Dual therapy only recommended for 1 year (AHA/ACC) • Investigate • Jean, 57 yo female hospital discharge orders for Clopidogrel, ASA, MetoprololSuccinate, Lisinopril, Lipitor, Nitroglycerin SL, oxycodone, Hydrocodone/APAP • Sounds post-PCI to me… • No intervention, dual therapy indicated (AHA/ACC)

  8. References • Bhatt, B., Fox, D., Hacke, W., et al, (2007) Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events. NEJM 2007;354:1706-17. Retrieved from http://content.nejm.org/cgi/content/full/354/16/1706 on 01/21/2007 • The GUSTO Investigators. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 1993;329:673-82. Retrieved from http://content.nejm.org/cgi/content/full/329/10/673 • Smith, S., Allen, J., Blair, S., AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update . Retrieved from http://circ.ahajournals.org/cgi/content/full/113/19/2363 • Standards of Medical Care in Diabetes—2007 AMERICAN DIABETES ASSOCIATION Retrieved from http://care.diabetesjournals.org/cgi/reprint/30/suppl_1/S4