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Differential Gene Expression between Han Chinese and Japanese

Differential Gene Expression between Han Chinese and Japanese. Yuan Yuan Prof . Shuhua Xu’s group Population genomic group PICB. Chinese and Japanese are very similar in phenotype. Expression variation among Chinese and Japanese individuals.

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Differential Gene Expression between Han Chinese and Japanese

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  1. Differential Gene Expression between Han Chinese and Japanese Yuan Yuan Prof. ShuhuaXu’s group Population genomic group PICB

  2. Chinese and Japanese are very similar in phenotype.

  3. Expression variation among Chinese and Japanese individuals Illumina's commercial whole genome expression array, Sentrix Human-6 Expression BeadChip version 2 These arrays utilize a bead pool with ~48,000 unique bead types Each with several hundred thousand gene-specific 50mer probes attached. Differently expressed

  4. Genome locations of 768 DE genes

  5. Functional enrichment of 768 DE genes

  6. Identify local (Cis) and distant (Trans) genetic regulators that associate with gene expression difference

  7. Distribution of cis-associations(SNPs) relative to the transcription start site (TSS)

  8. Genetic contributions to total expression variation for 11 cis-genes

  9. Cis-gene vs GWAS trait

  10. CTSS vscis-SNPs

  11. Acknowledgment Dr. ShuhuaXu Yang ling, Lu dongsheng, Shi meng, Lou haiyi Jin wenfei, Pankaj All in population genomics group

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