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"Role of Key Signaling Molecules in T Cell Activation and Regulation"

This article explores the critical role of various signaling molecules in T cell activation and regulation, focusing on important proteins like ZAP-70, LAT, Grb2, and SLP-76. We discuss their functions in the signaling pathways initiated upon T cell receptor engagement, including GDP/GTP exchange, MAPK activation, and involvement in cellular responses. The interplay among these molecules, such as Cbl and Sos, highlights their significance in T cell biology and immune responses, providing insights into potential therapeutic targets for immune modulation.

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"Role of Key Signaling Molecules in T Cell Activation and Regulation"

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  1. RAS RAS z z p p LAT p p Cbl p p Sos Shc ZAP-70 GDP GTP Raf SH3-C SH2 SH3-N Y-P MAPK SLP-76 Grb2 KDa Molecules 185 Sos 116 Cbl 76 SLP-76 46 SHC 36 LAT 25 Grb2

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