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Comparative Cisplatin Sensitivity in Cancer Cell Lines and HEK293 Using RHOXF2 Overexpression

This study compares the cisplatin sensitivity of MCF7, A549, and HEK293 cells with empty vector or RHOXF2 overexpression. The data includes the percentage survival at different cisplatin concentrations, highlighting the impact of RHOXF2 expression on drug response. The findings reveal potential differences in drug sensitivity that may be attributed to gene modulation. Understanding such variations can contribute to personalized treatment strategies for cancer patients.

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Comparative Cisplatin Sensitivity in Cancer Cell Lines and HEK293 Using RHOXF2 Overexpression

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  1. a b MCF7_M2 A549_M2 Percentage survival Percentage survival log[cisplatin] (uM) log[cisplatin] (uM) c HEK293_M2 d IC50cisplatin treatment Percentage survival A549_M2 MCF7_M2 HEK293_M2 Empty vector, no dox 718nM 41.06uM 298.1nM Empty vector, with dox 1,454nM 58.59uM 267.2nM RHOXF2 vector, no dox 448nM 44.91uM 376.2nM RHOXF2 vector, with dox 1,099nM 88.17uM 752.5nM Additional File 10 log[cisplatin] (uM)

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