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Protein Self-Assembly

This review explores the role of protein self-assembly and misfolding in various genetic disorders, including Muscular Dystrophy, Sickle Cell Anemia, and Parkinson’s Disease. Muscular Dystrophy arises from improperly created protective proteins leading to muscle degradation. Sickle Cell Anemia results from gene mutations causing abnormal red blood cell shapes. Meanwhile, Parkinson’s Disease is associated with the gradual death of neurons, potentially linked to misfolded alpha-synuclein proteins. The common thread among these diseases is the critical importance of proper protein assembly in maintaining cellular function.

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Protein Self-Assembly

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  1. Protein Self-Assembly

  2. Disease Review • Muscular Dystrophy • Genetic disorder • A protein to protect muscle is not created properly • Causes muscles to weaken and break apart over time

  3. Disease Review • Sickle Cell Anemia • Genetic disorder • Mutation in genes causes proteins to misfold • Sickle cells have an abnormal shape compared to regular red blood cells

  4. Disease Review • Parkinson’s Disease • Possible causes: • Genes • Environmental factors • Neurons that control body movement slowly die • Body movement is affected, symptoms include: • Tremors • One cause being researched: • Misfolded proteins, called alpha-synuclein, clump at neuron surface and cause dopamine secreting brain cells to die

  5. Disease Review • After reviewing all of the diseases from yesterday, what was something you noticed that they all had in common? • Discuss with a partner

  6. Self Assembly • Process in which an unorganized system will spontaneously form an organized structure • When proteins misfold or do not self assemble correctly, problems occur • Happens commonly at theNANO SCALE

  7. Self Assembly • http://www.youtube.com/watch?v=nbzpHRgrRBY • Module presentation

  8. After Module • After module, question for thought: • Who here has a messy room? • If you were to shake your room really hard and at the right temperature, would everything come together in it’s own place?

  9. Citations • http://www.stemcellmd.org/conditions-treated/genetic-disorders/muscular-dystrophy/ • http://www.whatayear.org/11_06.html • https://www.blackaids.org/news-2012/1459-sickle-cell-disease-cuts-hiv-risk-in-us-blacks-400000-person-review • http://www.whatayear.org/11_06_whiteboard.html

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