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European trial on reduction of cardiac events with perindopril in stable coronary artery disease

European trial on reduction of cardiac events with perindopril in stable coronary artery disease

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European trial on reduction of cardiac events with perindopril in stable coronary artery disease

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  1. EUROPA Trial European trial on reduction of cardiac events with perindopril in stable coronary artery disease Presented at European Society of Cardiology 2003

  2. EUROPA Trial 12,218 low-risk patients with stable coronary artery disease Randomized, double-blind, placebo-controlled • Perindopril • 8 mg/day • n=6,110 • Placebo • n= 6,108 • Endpoints (follow-up mean 3.4 years): • Primary – Composite of CV mortality, nonfatal MI, and cardiac arrest • Secondary – Composite of total death, nonfatal MI, and cardiac arrest; heart failure; revascularization (PCI/CABG); and stroke European Society of Cardiology 2003

  3. EUROPA Trial CV Mortality p=0.107 CV death/non-fatal MI/ cardiac arrest p=0.0003 European Society of Cardiology 2003

  4. EUROPA Trial • Among patients with stable coronary artery disease, treatment with the ACE-I perindopril was associated with a reduction in the primary endpoint of cardiovascular mortality, non-fatal MI, and cardiac arrest compared with placebo • ACE inhibitors have previously been shown to be effective in other patient populations, including heart failure, left ventricular dysfunction, and high-risk coronary artery disease patients • The present trial is the largest to show a benefit in stable, low-risk CAD patients