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Research Update

Research Update. Vivian S. Lee, M.D., Ph.D., M.B.A. Fall 2010. Targeting 7.5% annual growth in NIH Awards to improve ranking. Shared Goal: #25 in NIH Funding by 2015. ~$246M to be top-20 in FY20. Need ~$190M to be top-25 in FY15. +~$111 m. +~$55 m.

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Research Update

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  1. Research Update Vivian S. Lee, M.D., Ph.D., M.B.A. Fall 2010

  2. Targeting 7.5% annual growth in NIH Awards to improve ranking Shared Goal: #25 in NIH Funding by 2015 ~$246M to be top-20 in FY20 Need ~$190M to be top-25 in FY15 +~$111 m +~$55 m Non-ARRA up 5%/yr since FY08 (+20%/yr w/ARRA) - ARRA to-date - Non ARRA See appendix for assumptions. Source: Shulman grant projection model; econometric principles and algorithms that drive the modeling are proprietary and there is a patent pending

  3. Our Goals • Advance scientific discovery and innovation and foster a highly collaborative model of interdisciplinary scientific investigation • Improve productivity and enable growth • Facilitate research through effective administration • Invest in training and career development • Stay at the cutting edge of enabling technologies and shared resources

  4. Faculty Recruitment • Science Strategy Committee • Review of all TT or tenured research faculty recruits • Ensures highest caliber • Enables better integration of new recruits into the community • Cross-departmental mentoring • Since 2007, • 76 recruits reviewed • 5 denied • 71 approved • 45 accepted • 20 declined • 6 pending • Strategic Areas • Cancer Institute • Musculoskeletal Institute • Neuroscience Institute • Cardiovascular Institute • Children’s Health • I3: immunology, inflammation, infection* • Public health and population sciences* • Other areas of focus • Diabetes, metabolism, and obesity • Genetics and epigenetics • Stem cells • Drug discovery • Imaging

  5. 11% of the T/TT Faculty have been recruited in past 3 years Profile of Tenure/Tenure Track Faculty 5 * Excludes 2 T/TT assistant professors recruited between FY08 and FY10 who have left the organization

  6. Most Recruited Faculty Meet or Exceed Grant Salary Coverage Plan 46 of the T/TT faculty recruited between FY08 and FY10 had expected or actual salary coverage on grants. Of these, 32 are at or above targeted grant salary coverage levels. Number of FY08 – FY10 Recruits by Grant Salary Coverage Variance For Grant Salary Coverage To-Date 6

  7. Senior Recruits Meet or Exceed Average NIH Awardsfor Their Rank While it is too early to judge the success of T/TT recruits at the Assistant level, those at the Associate and Professor level are performing well in terms of awards generated Annual Awards per T/TT Faculty Member by Level ($ 000s) 7 *Note that only 6 of 42 Assistant level recruits have been here 3 full years and only half have been here 2 full years, so comparison to the entire cadre of assistant professors, many of whom are much further along in their careers, is setting an unrealistically high bar

  8. New NYU Faculty Recruits (as of 7/1/10)

  9. New NYU Faculty Recruits (as of 7/1/10)

  10. Ann Marie Schmidt, M.D.Iven Young Professor of EndocrinologyDirector, Diabetes Research Program • Identified and characterizing RAGE molecule and its role in the development of complications of diabetes, leading to their first antagonist drug in early phase II clinical trials • Previously, Columbia Department of Surgery • NYU alumna, Solomon Benson Alumni Achievement Award recipient • PI • PPG (NIA): Aging & Vulnerability to Ischemia • PPG (NHLBI): RAGE and mechanisms of vascular dysfunction • Project & Core leader on a 3rd PPG (RAGE, nerve injury, regeneration & aging) • JDRF Scholar, several JDRF grants • New 3 yr $2.4m PPG from JDRF: RAGE signal transduction: Novel treatments for T1 diabetes complications

  11. Ravichandran Ramasamy, Ph.DAssociate Professor of MedicineDiabetes Research Program • Investigating aldose reductase pathway as target for therapy to prevent complications of diabetes • Previously, Columbia Department of Surgery • PhD Loyola University of Chicago, Postdoc UT Dallas and UC Davis • PI • Project Leader, PPG (AMS): Polyol pathway & mechanisms of ischemic injury in aging, Animal experimentation Core. • R01 (NHLBI): RAGE, diabetes, and myocardial infarction • Several JDRF grants

  12. Shi-Fang Yan, M.D.Associate Professor of MedicineDiabetes Research Program • Investigating biochemical and signaling mechanisms by which PKCbeta and EGR-1 contribute to lesion development and progression in atherosclerosis • Previously, Columbia Department of Surgery • MD, Fujian Medical School, China, Postdoc Molecular Biology Beijing Union Medical University and Columbia University • PI • Project and Core Leader, PPG (AMS): AR & AGE-RAGE in Aging: impact on endothelial and vascular stress; Transgenic core • R01 (NHLBI): EGR-1, PKC beta, signaling and atherosclerosis • Several JDRF grants

  13. Chunyuan Jin, M.D., Ph.D.Assistant Professor of Environmental Medicine • Research goals: mechanisms of transcriptional regulation by unstable H3.3/H2A.Z NCPs and the role of these in T-acute lymphoblastic leukemia • Previously, postdoc NIDDK: Characterizing properties and genome-wide profiling of nucleosomes containing different histone variants (Felsenfeld) • PhD, Gene Engineering Division, BioResource Center & Tokyo University: Epigenetic regulation of differentiation of the mbryonic carcinoma cells • Pubs • Jin C… Felsenfeld G. H3.3/H2A.Z double variant-containing nucleosomes mark ‘nucleosome-free regions” of active promoters and other regulatory regions. Nat Genet 2009; 41:941 • Jin C & Felsenfeld G. Nucleosome stability mediated by histone variants H3.3 and H2A.Z. Genes & Dev 2007; 21:1519 • Jin C & Felsenfeld G. Distribution of histone variant H3.3 in erythroid cell lineage. PNAS 2006; 103:574. • Jin C…Yokoyama KK. Transcrition factor JDP2 is involved in histone modification and nucleosome assembly. Nat Struct Mol Biol 2006 (Cover)

  14. Suresh Cuddapah, Ph.D.Assistant Professor of Environmental Medicine • Research goals: identify causes for aberration in the chromatin domain structure that leads to tumorigenesis—role of insulator binding protein CTCF; molecular and epigenetic basis of mixed lineage leukemia. • Previously, Staff scientist, NHLBI • PhD, Biotechnology, Central Food Technological Research Institute, India; MPhil, MSc. Zoology, Loyola College, Univ of Madras, India • Pubs • Barski A, Jothi R, Cuddapah S* (co-1st)…Zhao K. Chromatin poises protein-coding and miRNA genes for expression. Genome Research 2009;19:1742. • Cuddapah S…Zhao K. Global analysis of the insulator binding protein CTCF reveals demarcation of active and repressive chromatin domains. Genome Research 2009; 19:24. • Cuddapah S…Zhao K. Transcriptional enhancer factor 1 (TEF-1/TEAD1) mediates ativation of IFITM3 gene by BRG1. FEBS Letters 2009;582:391. • Barski A, Cuddapah S* (co-1st)…Zhao K. High-resolution profiling of histone methylations in the human genome. Cell 2007;129:823. • Roh T-Y, Cuddapah S* (co-1st)…Zhao K. The genomic landscape of histone modifications in human T cells. PNAS 2006; 103:15782.

  15. Huilin Li, Ph.D.Assistant Professor of Environmental Medicine, Division of Biostatistics • Research goals: • Impact of error in covariate prevalence estimates and use of hierarchical models to improve prevalence estimates • GWAS: analyze associations between genetic variants and secondary phenotypes (CA-125) • Trend test for association for complex diseases • Previously, Research fellow, Biometrics Branch, Div Cancer Epidemiology (M. Gail, NCI) • PhD, Univ of Maryland (Lahiri): Small area estimation: an empirical best linear unbiased prediction approach • Awards: DCEG Fellows Award for research excellence • Pubs (5) • Li H, et al. Using cases from genome-wide association studies to strengthen inference on the association between single nucleotide polymorphisms and a secondary phenotype. Genetic Epidemiology, in press • Li H, et al. Covariate adjustment and ranking methods to identify regions with high and low mortality rates. Biometrics, in press. • Li H and Lahiri P. Adjusted maximum likelihood method in the small area estimation problem. J of Multivarate Analysis. 2010; 101:882

  16. Mario Delmar, M.D.Professor of Medicine, Cardiology Division • Leading expert in cellular electrophysiology and arrhythmia mechanisms, focusing on cell junctions, establishing “ball and chain” gating model for gap junction channels, developing peptides for anti-arrhythmic therapies • Previously, University of Michigan, Center for Arrhythmia Research • Originally trained in Mexico • Postdoctoral fellow, SUNY Upstate (Jose Jalife) • SUNY Upstate: Prof and Vice-Chair • Fellow AHA, Heart Rhythm Society • PI • R01 (NIGMS): pH regulation of connexin43 • RC1 (NHLBI): Stem cells and the fibroblast/adipocyte lineage in arrhythmogeniccardiomyopathy • Project leader P01 (Jalife) Role of Cx43 regulation in cardiac function • Project leader P01 (Jalife) Arrhythmia mechanisms in two inherited cardiac diseases • Leduc Transatlantic Network, Core member

  17. Matthew Fitzgerald, Ph.D.Assistant Professor of Otolaryngology • Research goals: development of real-time processing to optimize fitting of bilateral cochlear implants, reduce time to adapt to electrical stimulation • Previously, Postdoc, NYU Otolaryngology (Svirsky) • Ph.D. Northwestern Univ, Communication sciences and disorders • PI • K99/R00 (NIDCD): Optimizing fitting of bilateral cochlear implants • Pubs (9) • Fitzgerald MB…Svirsky MA. Reimplantation of hybrid cochlear implant users with a full length electrode after loss of residual hearing. Otol Neurotol 2008; 29:168. • Fitzgerald MB…Svirsky MA. The effect of perimodiolar placement on speech perception and frequency discrimination by cochlear implant users. Acta Otolaryngologica 2007;127:374. • Fitzgerald MB & Wright BA. A perceptual learning investigation into the pitch elicited by amplitude-modulated noise. J Acoustical Soc of Am. 2005;118:3794

  18. Ryan Branski, Ph.D.Assistant Professor of Otolaryngology, NYU Voice Center • Research goals (50%): Investigating the role of COX-2 in vocal fold wound healing, effects of KTP laser on scarred vocal folds • Previously, Assistant attending scientist, MSKCC • PhD Health and Rehabilitation Sciences, U. Pittsburgh • Clinical Fellow, Speech/Voice Pathology, U. Pittsburgh • PI • R03 (NIDCD): Inflammation and fibrosis of the vocal folds • Pubs (20) • Branski RC…Kraus DH. Cigarette smoke and reactive oxygen species metabolism: Implications for the pathophysiology of Reinke’s Edema. Laryngoscope 2009;119:2014. • Branski RC…Felsen D. The effects of transforming growth factor (TGF)-b1 on human vocal fold fibroblasts. Annals of Otology, Rhinology, and Laryngology. 2009; 118:218. • Branski RC…Agrawal S. Dynamic biomechanical strain inhibites IL-1b-induced inflammation in vocal fold fibroblasts. J of Voice. 2007;21:651.

  19. Dimitris Placantonakis, M.D., Ph.D.Assistant Professor of Neurosurgery • Research goals: genetic analysis of developmentally regulated miRNAs expressed in human embryonic stem cell-derived motor neurons; developmental profiling of human glioblastomas using bacterial artifical chromosomes • Previously, Resident/Fellow Neurosurgery Cornell • Postdoc, MSK, Enriched motor neuron populations derived from BAC-transgenic human embyronic stem cells (Studer, Tabar) • MD/PhD (MSTP, AOA) NYU; PhD (Welsh): On the role of gap junctional communication in inferior olivary oscillations • Pubs (19) • Placantonakis DG…Schwartz TH. Bilateral intracranial electrodes for lateralizing intractable epilepsy. Neurosurgery 2010;66:274 • Placantonakis DG…Studer L. BAC transgenesis in human ES cells as a novel tool to define the human neural lineage. Stem Cells. 2009;27:521. • Placantonakis DG … Welsh JP. Continuous electrical oscillations emerge from a coupled network: A study of the inferior olive using lentiviral knockdown of connexin36. J Neuroscience 2006;26:5008 • Placantonakis DG … Welsh JP. Fundamental role of inferior olive connexin 36 in muscle coherence during tremor. PNAS 2004; 101:7164

  20. Eli Rothenberg, Ph.D.Assistant Professor of Biochemistry • Research goals: • Advanced biophotonics and superresolution microscopy: modified QDs for 3D microscopy in live cells • Single molecule microscopy: tracking viral infection pathways and cellular delivery of genetic materials • Novel nanoprobes and nanotechnology-based assays: colloidal metallic and semiconductor nanoparticles, metallic nanoparticles, lipid vesicles • Postdoc, Univ of Illinois, Urbana (Taekjip Ha), Advanced optical methods and biophotonics, single molecule microscopy • PhD, Hebrew University (Uri Banin): Optical and electronic propertites of ensemble and single nanocrystals semiconductor quantum rods • Pubs (15) • Rothenberg E & Ha T. Single molecule FRET analysis of helicase functions. Methods in Molecular Biology 2009; 587:18 • Rothenberg E…Ha T. Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes. PNAS 2008;205;20274 • Rothenberg E…Ha T. MCM fork substrate specificity involves dynamic interaction with the 5’ tail. JBC 2007;282:34229 (cover)

  21. David Fenyö, Ph.D.Associate Professor of Biochemistry, CHIBIHead, Computational Proteomics Laboratory • Research goals: • Proteomic data analysis, methods and databases for protein identification, characterization and quantification using mass spectrometry-based technologies • Previously, Senior Research Associate, Rockefeller University; ProteoMetrics (start-up), President, Director of Proteomics at Genomic Solutions; Staff Scientist at GE • PhD, Uppsala University (Sweden) • Pubs (>80) • Sekedat MD, Fenyö D, Tackett AJ, Aitchison JD, Chait BT. Direct Genome-Wide View of DNA Replication Fork Progression in S. cerevisiae, From the Perspective of the GINS Complex. Molecular Systems Biology. 6 (2010) 353.  • Eriksson J & Fenyö D. Predicting the Success Rate of Proteome Analysis by Modeling Protein Abundance Distributions and Experimental Designs. Nature Biotech, 25 (2007) 651-655. • Fenyö D & Beavis RC. A method for assessing the statistical significance of mass spectrometry-based protein identifications using general scoring schemes. Anal Chem. 75 (2003) 768-74. • Eriksson J, Chait BT, & Fenyö D. A Statistical Basis for Testing the Significance of Mass Spectrometric Protein Identification Results. Analytical Chemistry 72 (2000) 999-1005.

  22. Collaborations and Teams Total $ NIH Funding Total Count of NIH Grants A comparison between NYULMC and the Milestone Competitors, focusing on the 2009 awards for non-R01 grants, identifies potential opportunities in the U series and P series grant areas. Note: Fund amounts in $MM Other: D Series, M01, S Series, F Series, G Series

  23. Strategic Initiatives: Interdisciplinary Research • Centers of Excellence • Many active programs and initiatives • Seminars, seed grant programs, new collaborations • Addiction, Brain Aging and Urological Disease retreats • CoE renewals/RFA Fall 2011 • New Institutes • Neuroscience Institute • I3 (Inflammation, Infection, Immunology) • Public Health • Sources of Internal support: • PPG Development team (Henry Sun, Claudio Basilico, co-Chairs) • Continues to review proposals for up to $100,000 in funding • More active role in reviewing proposals (SPORE), earlier stages • Workshop planned for early 2011 • NYU-Geisinger collaboration: Seed grants in health services research • NYU-Polytechnic Institute

  24. Neuroscience Institute Update • Neuroscience Institute Director: Richard Tsien • R. Lehmann, chair • Neuroscience training grant funded • Co-PI: Stewart Bloomfield and Eric Klann • Neuroscience Advisory Committee recommendations • E. Ziff, chair • Neuroscience Prize • Recruiting graduate and MD/PhD students • Ideas for enhancing career development/support for junior faculty • Core facilities • And more • Neuroscience website http://neuroscience.med.nyu.edu/

  25. Bringing together the expertise Microbiology Pathology Infectious Disease Medicine/Microbiome Rheumatology Parasitology Skirball Molecular Pathogenesis And most clinical departments CoE proposals Inflammation Microbiome Global Health Asthma Multiple Sclerosis Musculoskeletal Disease (Rheumatology) And others I3: Inflammation, Infection, Immunology • Develop the training program, coordinate seminar series, website, strengthen the community • First I3 Retreat: May 12, 2010, Second retreat in planning for June 2011 • Linda Miller, Assoc Dean for Basic Science, coordinating efforts

  26. Public Health Verizon building acquisition 30th St between 2nd and 3rd avenues 3½ floors programmed for CTSI and public health research, including lecture room Home to CTSI Health Informatics and Bioinformatics (CHIBI) New Department of Biostatistics and Epidemiology Community health Population Science—comparative effectiveness, decision analysis, health economics, and more Coordinated with the Cancer Institute Population Science initiative New initiative: Innovations in health care delivery Exploring new recruits jointly with Stern/Wagner in health management and policy

  27. Opportunity for Increased Clinical Research is Also Substantial NIH Cardiovascular Funding: Comparison of NYU and MSSM ($ millions) NIH Awards Distribution at NYU & MSSM – Basic Science v. Clinical Departments ($millions) Note: Classification of grants as “cardiovascular” is based on NIH Research, Condition, and Disease Category (RCDC) designations; classification of grants as “clinical” is based on NYULMC review.

  28. CTSI News… The CTSI Translational Research/Novel TechnologiesProgram awarded 20 Pilot Projects (T1-T3) totaling $770k. A new RFA for CTSI Pilot Projects was issued 9/1/10. The CTSI Translational Research Education and Careers (TREC)Core awarded: -6 TL1 trainees and 4 KL2 scholars (one CTSI KL2 scholar recently received a K23 grant). The Translational Research-in-Progress (TRIP) seminar (sponsored by the Department of Medicine and the CTSI) provides a forum for presentation of work-in-progress by Basic/Clinical and Translational scientists The Community Engagement and Population Health Research (CEPHR) Core and the Value and Comparative Effectiveness Core (DGIM) are partnering on a number of grants in health services research The CTSI Governance, Study Design & Biostatistics, and Bioinformatics Cores developed the CTSI Protocol Studios to offer investigators an opportunity to have protocols and manuscripts reviewed and critiqued by an expert faculty panel. The Best Practices Integrative Informatics Consultation Service(BPIC) of the CTSI Bioinformatics Core has performed ~100 formal consultations since October 2009, and is instrumental in developing the federated data warehouse proposal, and in implementing the Find-A-Researcher 2.0 prototype: Open Office Hours every week The CTSI Clinical Research Center (former GCRC) maintains >90 active studies and anticipates two dozen new inpatient and 20 outpatient studies this year

  29. Our Goals • Advance scientific discovery and innovation and foster a highly collaborative model of interdisciplinary scientific investigation • Improve productivity and enable growth • Facilitate research through effective administration • Invest in training and career development • Stay at the cutting edge of enabling technologies and shared resources

  30. Understanding the pressures: Productivity and Growth • Academic medical centers are businesses with unique missions • The aim of research administration is to provide a rich environment for the conduct of great research and to shield PIs as much as possible from the business side of the business • The reputation of an academic medical center depends heavily on research: • Major programs and institutes with critical mass • Recruit outstanding faculty • Improved and expanded space • Core facilities and technologies • To persuade the Board to invest in research, we must make excellent use of our resources • Improve productivity of some faculty • Improve effectiveness of our support services, reduce duplication (IT, finance etc) • Use space more efficiently • We need to validate the investments in research to our Board through the quality of the science, impact of discovery and innovation, and through improved grant and technology transfer revenue

  31. Faculty Productivity • AEC salary coverage minimum for 2010-11 = 60% • New incentive/rewards for well-funded investigators • Emphasis on salary coverage significantly exceeding AEC targets • Emphasis on multiple NIH grants • Emphasis on NIH PPG/Center grants

  32. Overall, our NIH activity is highly reliant on a small number of highly productive faculty… Profile of Top-50 Faculty in terms of NIH Successes FY08 – FY10 Of NIH Successes (lifetime value of awarded grants) Of NIH Proposal Value Of Active NIH Submitters 32 Note: Includes 13 faculty members who are holders of active “mega grants” valued at >$5 million each

  33. Better performers convert a higher ratio of proposals to successes (35) (35) (34) (36) (35) (35) (34) (36) (84) (84) Among 140 Baseline T/TT faculty with NIH Successes (excludes those with active “mega-grants” & recent recruits) Among 140 Baseline T/TT faculty with NIH Successes (excludes those with active “mega-grants” & recent recruits) 33

  34. Yet even our most productive faculty are not at full capacity ~ $20 - $30 million additional “capacity” in our already successful faculty (or 2 R01s with $375K each) 34

  35. Our Facilities also appear to be below full capacity ~ $30 million additional “capacity” in our current research space 35

  36. Space: Relocations Increasing space efficiency Relocating approx 70,000 SF research space in Rusk, Tisch, Perelman (total 185,000 SF) To manage relocations and growth: Most laboratories that have no funding have been asked to close Each major administrative/space unit should be expected to “contribute” space for relocations (faculty, cores, etc) Relocating their Rusk/Perelman/Tisch faculty into their existing space House core facilities Other relocations as needed With relocation “duty” fulfilled, departments are recruiting Think about “dry space” recruits

  37. New Space New research space, partly for relocation, mostly for growth Verizon (available 2010-2011): Dry space ERSP (available 2012): Wet bench Varick Street (available 2011): Wet and Dry space New building…

  38. New Building! New research building: 300,000 SF Architect selected Occupancy by end 2014 Neuroscience and i3

  39. Space Policy and Management Space Policy drafted, to be rolled out in coming months Space survey currently underway NIH indirect rate negotiation New space management software New Space Management Advisory Committee

  40. Understanding the pressures: Productivity and Growth • Academic medical centers are businesses with unique missions • The aim of research administration is to provide a rich environment for the conduct of great research and to shield PIs as much as possible from the business side of the business • The reputation of an academic medical center depends heavily on research: • Major programs and institutes with critical mass • Recruit outstanding faculty • Improved and expanded space • Core facilities and technologies • To persuade the Board to invest in research, we must make excellent use of our resources • Improve productivity of some faculty • Improve effectiveness of our support services, reduce duplication (IT, finance etc) • Use space more efficiently • We need to validate the investments in research to our Board through the quality of the science, impact of discovery and innovation, and through improved grant and technology transfer revenue

  41. Research Administration

  42. Linda J. Miller, Ph.D.Associate Dean for Basic Science Develop, lead, and coordinate the basic science and translational components of major collaborative research initiatives Previously, US executive editor for Nature and the Nature journals Founding editor of Nature Immunology Editor at Science for 12 years Ph.D. Harvard University, Immunology (T. Springer) Post-doc, NCI (J. Ihle)

  43. Laura AhlbornVice President for Science Strategy Integrating planning around research recruiting, space, and other resources as necessary to achieve strategic goals, clarify space management principles and coordinate research moves for campus transformation Previously, University of Pennsylvania School of Medicine and Health System, Senior Executive Director of Research Planning and Management where she led research strategic planning process and represented needs of faculty in planning a new 400,000 SF translational research building 20 years as consultant for academic medical centers and health systems BA Psychology, Wesleyan

  44. Anny FernandezAdministrator, Office of Science & Research Oversee administrative affairs for OSR including budget oversight, liaison with external collaborators, point of contact for departmental administrators, Centers of Excellence, and affiliates. Previously, Mt Sinai Medical Center, Department of Cardiothoracic Surgery Departmental Administrator for Parasitology Department, NYU Administrative roles at Columbia University , NYC Department of Education Budget Office, United Nations M.S. Social Administration, Columbia

  45. Our Goals • Advance scientific discovery and innovation and foster a highly collaborative model of interdisciplinary scientific investigation • Invest in training and career development • Facilitate research through effective administration • Stay at the cutting edge of enabling technologies and shared resources • Improve productivity and enable growth

  46. Technology Transfer FY10 increases in activities (127 inventions received, 56 US patents issued, 40 licenses, 6 start-ups) Applied Research Support Fund (ARSF) reinstituted 2 years ago and expanded. 53 submissions and 8 awards in FY10 of up to $75K each. Historically, $25M in license and research revenues from $1.6M in ARSF funding (15:1). Venture capital fund created in 2010 Frank.rimalovski@nyumc.org Contact Office of Industrial Liaison to discuss new ideas, and collaborations with industry. Under patent law, important to file patent application before publishing or presenting.

  47. SPA • Interim Director: Tony Carna • Grants budgeting initiative • Myth: modular grants have a better chance of getting funded than nonmodular budgets • Reality: well-justified budgets reflect well thought out experiments and a seasoned investigator • Carna’s workshop on budgeting tips (online): • Budget enough salary support for PI (25-35%) • Include statisticians, informaticians at sufficient support • Budget animals, cores, contingencies appropriately • Budget justification template text under development

  48. Our Goals • Advance scientific discovery and innovation and foster a highly collaborative model of interdisciplinary scientific investigation • Improve productivity and enable growth • Facilitate research through effective administration • Invest in training and career development • Stay at the cutting edge of enabling technologies and shared resources

  49. Faculty Development • Leadership development and management skills course for faculty • Grantsmanship course and online resources • Physician Scientist Training Program

  50. LEADS Leadership, Education and Development for Scientists Program November 1 – 3, 2010 Ken Broadhurst Svetlana Yedreshteyn Deirdre Wincewski Dr. Vivian Lee 50

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