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10/14/2010 Andrej Mosat, LPPD, UIC. Research update. Cyclosporine A Paper. 1. Paper for Journal of Theoretical Biology on Cyclosporine A delivery in a Rat and a Human. Main Points.
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10/14/2010 Andrej Mosat, LPPD, UIC Research update
Cyclosporine A Paper • 1. Paper for Journal of Theoretical Biology on Cyclosporine A delivery in a Rat and a Human
Main Points • 1. All organs in a mammalian body are interconnected. Closed vasculature multicompartmental model of arbitrary complexity can simulate novel drug's biodistribution reliably • 2. Simple first order model as a set of partial differential equations leads to more insight than complicated models with curve fitting. • 3. A case study supporting the two solution approaches will be presented on Cyclosporine A IV bolus injection in Sprague Dawley rats.
Methods • We show two solution approaches to the network and kinetic inversion problem: • a.) numerically solving a networked system of DAEs by "DASSL" • b.) numerically solving the system of PDE`s by "the sensitivity method“ • - automatic equation generator • - DAE solver • - Analytical solution for systems of DAEs cannot be obtained in general
Case study • Rat, bolus IV Injection vs. • Human, bolus IV Injection Challenges: Unclear measurement data. Tail ? Different Proteins in Rats/Humans
Mass balance "R:\matlab\from Eric\Cyclosporin A\20101030-FIG-CyA-Mass.jpg"
Blood/Plasma "R:\matlab\from Eric\Cyclosporin A\20101030-FIG-CyA-Mass.jpg"