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GBV-C Effects on T Cell Activation and Chemokine Induction in HIV-Infected Individuals

This study investigates the impact of GBV-C on T cell activation and chemokine expression in HIV-infected patients. Results indicate that GBV-C replication in T and B cells is limited, yet it significantly downregulates B cell activation and affects monocyte CCR5 expression. The study uses flow cytometry to measure CD4 cells and HIV viral load, revealing that GBV-C diminishes NK cell activation and alters CCR5/CXCR4 expression in monocytes. The findings suggest that GBV-C may play a role in prolonging survival in HIV-infected individuals.

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GBV-C Effects on T Cell Activation and Chemokine Induction in HIV-Infected Individuals

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  1. GBV-C blunts T cell activation & proliferation GBV-C induces chemokines GBV-C CCR5 and CXCR4 on CD4 cells GBV-C replicates in T and B cells P=0.01 N=11 N=13 N=11 N=9 Study Design ns UIHC HIV Clinic Patients Invitation – Informed Consent Heparinized Blood/Serum Obtained CD4, HIV VL measured Serum => GBV-C VL Cells => flow cytometry Does GBV-C alter B cell & NK cell activation or alter monocyte CCR5/CXCR4 expression?

  2. P=0.018 P=0.009 B cell activation: GB+ < GB- p=0.024 HIV Viremic GB+ < GB- p=0.018 NK cell activation: CD56dim/CD16+: NS CD56brt/CD16-: If HIV RNA neg: NS If HIV RNA pos: GB+ < GB- p=0.009

  3. Conclusion: • GBV-C replication in vivo • Diminishes B cell activation • Blunts CD16+ NK cell activation • Downregulates monocyte CCR5 • GBV-C replicates in T and B cells; however, replication limited to a very small percentage of cells. • Replication has not been shown in NK cells or monocytes. Effect in these cells may be due to induction of chemokines and/or cytokines • The effect of GBV-C activation on T and B lymphocytes, NK cells and monocytes may contribute to prolonged survival in HIV- infected individuals. Monocyte CCR5 expression GB+ < GB- p=0.009 HIV RNA+: GB+ < GB- p=0.03 CXCR4 GB+< GB-, but NS P=0.03

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