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This overview explores the structure and function of chromosomes in cell reproduction, primarily focusing on DNA, which stores genetic information through genes composed of four bases: adenine, thymine, guanine, and cytosine. It distinguishes between sex chromosomes (XY for males, XX for females) and autosomes. The text reviews chromosome duplication, a karyotype example, diploid versus haploid cells, and the processes of mitosis and meiosis, detailing each stage of cell division. Finally, it contrasts sexual and asexual reproduction, highlighting key differences in genetic variation.
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DNA: stores all genetic information -genes:a hereditary unit of DNA -4 bases: -Adenine -Thymine -Guanine -cytosine
DNA in the Cell • Chromosome • Supercoil • Subcoil • One coil • DNA with histine protein • DNA
Chromosome Types • Sex Chromosomes: determines the sex of an organism -XY: male -XX: female • Autosomes: All other chromosomes of an organism
Homologous Chromosomes: two copies of each autosome – same size, shape, and genes
Karyotype: photomicrograph of chromosomes Humans have 22 pairs of autosomes and 1 pair of sex chromosomes
Diploid Cells (2n): cells with both sets of chromosomes (both homologous pairs) 46 chromosomes/23 pairs in humans
“C” words of Cytology 1. Chromosome: condensed genetic material • Chromatid: one of two identical copies of DNA • Centromere: region that joins the chromatids
“C” words of Cytology • Centrioles: cylindrical structures that assist in cell division • Centrosome: dark regions in the cytoplasm that create spindle fibers
1. Mitosis: cell division which produces 2 diploid, identical cells
Cell Life Cycle Interphase: G1, S, and G2 G = growth S = Synthesis M phase: mitosis – nuclear division Cytokinesis: cytoplasm division
Interphase 1. Interphase: DNA not visible -nucleus still intact
Phases of Mitosis • Prophase: chromosomes become visible -nucleus disintegrates
Phases of Mitosis • Metaphase: chromosomes connect at the centromere to spindle fibers -line up at the equatorial plate
Phases of Mitosis • Anaphase: spindle fibers recede -pull chromosomes apart -chromosomes retreat to opposite ends
Phases of Mitosis • Telophase: nucleus reforms Cytokinesis splitting the cell -2 daughter cells are formed
Homologous Chromosomes: identical chromosomes – one from each parent
Mitosis vs. Meiosis Mitosis Meiosis -produces four offspring cells of 1n -two cell division cycles (meiosis I & 2) -produces gametes -chromosomes cross over -Produces two offspring cells of 2n -One cell division cycle -produces body cells -no chromosomes cross over
8 Stages of Meiosis Prophase I Metaphase I Anaphase I Telophase I Prophase II Metaphase II Anaphase II Telophase II Meiosis I Meiosis II
Prophase I -Chromatids form -Homologous chromatids pair up to form tetrads
Metaphase I -tetrads line up at equatorial plate -Crossing over: breaking off of arms of chromatids and switching places on another homologous chromosome
Anaphase I -tetrads are pulled apart
Telophase I -cytokinesis occurs
Spermatogenesis: meiosis that produces sperm Produces 4 fertile cells; in humans @ 400 billion
Oogenesis: meiosis that produces egg cells Produces 1 fertile cell; about 400 in a lifetime
Types of Reproduction • Sexual reproduction: offspring are the result of combination of parental genetics • Asexual reproduction: no exchange of genetic information – genetically identical to parent