Enzymes pp 96 - 102
Enzymes All enzymes are proteins; not all proteins are enzymes. Most enzymes have an –aseending. ATPase amylase
Enzymes enzyme -
Steps to Enzyme Reactions Write out the 5 steps for an enzyme catalyzing a reaction
Substrate Binding active site
Substrate Binding R-groups
Enzymes activation energy EA
Reaction Progression Reaction Progession
Enzyme Energy Enzymes lower the activation energy (EA) of reactions.
enzyme-substrate complex Substrate Binding induced-fit model -
Substrate Binding Enzymes reduce EA by:
Limitations of Enzymes Why do enzymes operate at an optimal temperature and pH?
Enzyme Limitations cofactors– coenzymes– An apoenzymeis
Enzyme Inhibition competitive inhibitor – noncompetitive inhibitor –
Enzyme Regulation allosteric site – allosteric activator – allosteric inhibitor –
Feedback Inhibition A, B, C and D are molecules along a metabolic pathway. E1, E2 and E3 are enzymes required for this metabolic pathway. D is an allosteric inhibitor of E1.