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Lymph node pathology

Lymph node pathology. Lymph node histology. Functions Filtration of lymph Processing of Ag Differentiation of lymphocytes. Secondary lymphoid follicle Germinal centre mantle. Terminology. Lymphadenopathy Lymphadenomegaly Lymphadenitis Lymphoproliferation Lymphoma

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Lymph node pathology

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  1. Lymph node pathology

  2. Lymph node histology Functions Filtration of lymph Processing of Ag Differentiation of lymphocytes

  3. Secondary lymphoid follicle Germinal centre mantle

  4. Terminology • Lymphadenopathy • Lymphadenomegaly • Lymphadenitis • Lymphoproliferation • Lymphoma • Enlargement of LN: inflammation • Tumor – primary/secondary

  5. Lymphadenitisacute or chronic Classification predominant histologic pattern etiology Rarely biopsied

  6. Lymphadenitis - etiology MICROBIAL • viral • bacterial, mycobacterial • fungal • protozoal NONMICROBIAL - autoimmune storage dis. foreign mat. miscel.

  7. Lymph node inflammation Lymph node hyperplasia: 1. follicular 2. paracortical 3. sinuses 4. mixed patterns

  8. Lymph node inflammation - patterns • Follicular hyperplasia bacteria, RA, HIV(early), syphilis, Castleman dis. • Paracortical hyperplasia viruses, dermatopathies, vaccination, drug hypersensitivity, Kikuchi, SLE, draining pus or carcinoma

  9. Lymphadenitis - histological patterns • sinusoidal hyperplasia - lymphangiography, Whipple dis., sin. histiocytosis with massive lymphadenopathy, draining carcinoma • granulomas - TB, other mycobact., leprosy, Whipple, fungi, berylliosis, sarcoidosis, • Granulomatous-purulent:cat scratch, tularemia, lymphogr. venereum,Yersinia • mixed patterns: toxoplasmosis

  10. Regressive transformation of germinal centres

  11. Follicular hyperplasia

  12. Progressive transformation of germianl centres

  13. Sinus histiocytosis

  14. Lepra - globi

  15. Infectious mononucleosis

  16. Cat scratch disease

  17. Kikuchi lymphadenitis

  18. Bartonella henselaeCt scratch disease

  19. CMV

  20. Kimura disease

  21. Cryptococcosis

  22. Atypical mycobacteriosis

  23. Lymphogranuloma venereum

  24. Mycobacterium TB

  25. Pneumocystosis

  26. Syphilis

  27. TBC

  28. Toxoplasmosis

  29. Whipple disease

  30. Sinus histiocytosis with massive lymphadenopathy

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