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Molecular Interaction between EGFR and ErbB2 Signaling Pathways

Explore the intricate cross-talk between EGFR and ErbB2 pathways and their regulatory mechanisms in cell signaling. Uncover the key interactions and molecular targets in this dynamic signaling network.

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Molecular Interaction between EGFR and ErbB2 Signaling Pathways

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  1. RRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKG IWIPD RRLLQE ELVEPLTPSG PNQA +RILKETE +K +KVLGSGAFGTVYKG+WIP+ RRLLQERELVEPLTPSGE APNQAL LRILKETEF KKI KVLGSGAFGTVYKGLWIPE GENVKIPVAIKVLRENTSPKANKEILDEAYVMAG VGSPY VSRLLGICLTSTVQLVT GE VKIPVAIK LRE TSPKANKEILDEAYVMA V +P + V RLLGICLTSTVQL +T GEKVKIPVAIKELREATSPKANKEILDEAYVMA SVDNPHVCRLLGICLTSTVQL IT LVKSPNHVKITDFGLARLLD I DETEYHADGGKVPIKWMALESILRRRFTHQSDVWS LVK+P HVKITDFGLA+LL + E EYHA+GGKVPIKWMALESIL R +THQSDVWS LVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWS YGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMI YGVTVWELMTFG+KPYDGIPA EI +LEKGERLPQPPICTIDVYMI YGVTVWELMTFGSKPYDGIPA SEIS S ILEKGERLPQPPICTIDVYMI TK1 742 ErbB2 710 EGFR M5 loop 798 ErbB2 EGFR 766 * * TK2 851 ErbB2 QLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNV QLMP+GCLLD+VRE+ + + GSQ LLNWC +QIAKGM +YLED RLVHRDLAARNV 819 EGFR QLMPFGCLLDYVREHKDNI GSQYLLNWC VQIAKGMNYLEDRRLVHRDLAARNV 907 ErbB2 875 EGFR * 954 ErbB2 922 EGFR Suppl. Fig. 1 Marcotte et al. 2008

  2. Suppl. Fig. 2 Marcotte et al. 2008

  3. 4 4 10 10 3 3 10 10 FL4-H FL4-H 2 2 10 10 1 1 10 10 0 0 10 10 0 1 2 3 4 0 1 2 3 4 10 10 10 10 10 10 10 10 10 10 FL1-H FL1-H 4 4 10 10 3 3 10 10 FL4-H FL4-H 2 2 10 10 1 1 10 10 0 0 10 10 0 1 2 3 4 0 1 2 3 4 10 10 10 10 10 10 10 10 10 10 FL1-H FL1-H A EV EGFR EGFR YHAD TK Suppl. Fig 3 Marcotte et al. 2008

  4. A B Suppl. Fig 4 Marcotte et al. 2008

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