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What is a mutation???

What is a mutation???. GENETIC MUTATIONS. MISTAKES IN DNA. A MISTAKE CAN BE:. 1. A point mutation – substitution, addition, or removal of a single DNA base.

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What is a mutation???

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  1. What is a mutation???

  2. GENETIC MUTATIONS MISTAKES IN DNA

  3. A MISTAKE CAN BE: 1. A point mutation – substitution, addition, or removal of a single DNA base. 2. A frameshift mutation – a point mutation due to an addition or deletion of a DNA base that causes a major change in the genetic code.

  4. Sickle cell anemia is caused by a point mutation - substitution Val-his-leu-thr-pro-glu-glu Val-his-leu-thr-pro-val-glu-

  5. Muscular Dystrophy is caused by a frameshift mutation

  6. THE CAT SAW THE DOG

  7. CHANGE THE W TO A T: THE CAT SAT THE DOG CHANGE THE D TO AN H THE CAT SAW THE HOG

  8. MAJOR MISSENSE: REMOVE THE “C” THE ATS AWT HED OG This type of mutation causes a protein to be non-functional. It is a severe problem and can be lethal.

  9. MAJOR MISSENCE: INSERT AN “M” after the first “The”. THE MCA TSA WTH EDO G The body cannot make sense out of the incorrect protein, just as the sentence no longer makes sense to you.

  10. Nonsense • When a point mutation codes for a STOP in the middle of a sequence. Could be due to any of the point mutations. Nonfunctional dystrophin, the protein that helps attach your skeletal muscle to its surroundings.

  11. Some mutations involve whole chromosomes: 1. Deletion: A piece of a chromosome is lost because of breakage during cell division Cri du chat

  12. Inversion: A piece of a chromosome breaks off and reattaches backwards. The effect can belethal.

  13. Duplication: A portion of the chromosome is copied and placed in the same chromosome.

  14. Translocation: a piece of a chromosomes breaks off and reattaches to a non-homologous chromosome

  15. Non-disjunction: A chromosome fails to separate from its homologue during meiosis

  16. Turner’s Syndrome:

  17. Klinefelter’s Syndrome:

  18. Mutations in nature:

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