axin1 antibody

1. Anti-AXIN1 (C-terminal) polyclonal antibody Anti-AXIN1 (C-terminal) polyclonal antibody (DPAB-L20146) (DPAB-L20146) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION PRODUCT INFORMATION Antigen Description Antigen Description This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010] Immunogen Immunogen AXIN1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human AXIN1. Source/Host Source/Host Rabbit Species Reactivity Species Reactivity Human Conjugate Conjugate Unconjugated Applications Applications indirect ELISA: suitable Format Format Buffered aqueous solution Size Size 100μg Buffer Buffer Supplied in PBS with 0.02% sodium azide. Storage Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C GENE INFORMATION GENE INFORMATION Gene Name Gene Name AXIN1 axin 1 [ Homo sapiens (human) ] Official Symbol Official Symbol AXIN1 45-1 Ramsey Road, Shirley, NY 11967, USA Email: info@creative-diagnostics.com Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved

2. Synonyms Synonyms AXIN1; axin 1; AXIN; PPP1R49; axin-1; axis inhibitor 1; fused, mouse, homolog of; axis inhibition protein 1; protein phosphatase 1, regulatory subunit 49 Entrez Gene ID Entrez Gene ID 8312 mRNA Refseq mRNA Refseq NM_003502 Protein Refseq Protein Refseq NP_003493 MIM MIM 603816 UniProt ID UniProt ID O15169 Pathway Pathway AMER1 mutants destabilize the destruction complex; APC truncation mutants are not K63 polyubiquitinated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; AXIN mutants destabilize the destruction complex; Basal cell carcinoma; Beta-catenin phosphorylation cascade; C-MYC pathway Function Function GTPase activator activity; I-SMAD binding; R-SMAD binding; SMAD binding; armadillo repeat domain binding; armadillo repeat domain binding; beta-catenin binding; enzyme binding; identical protein binding; protein C-terminus binding; protein binding; protein complex scaffold; protein complex scaffold; protein homodimerization activity; protein kinase binding; protein kinase binding; protein self-association; receptor binding; signal transducer activity; ubiquitin protein ligase binding 45-1 Ramsey Road, Shirley, NY 11967, USA Email: info@creative-diagnostics.com Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved