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btk antibody

Anti-BTK polyclonal antibody can be provided from Creative Diagnostics.<br>https://www.creative-diagnostics.com/Anti-BTK-PAb-222926-147.htm<br>

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btk antibody

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  1. Anti-BTK (N-terminal) polyclonal antibody (DPAB- Anti-BTK (N-terminal) polyclonal antibody (DPAB- L20215) L20215) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION PRODUCT INFORMATION Antigen Description Antigen Description The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] Immunogen Immunogen BTK antibody was raised against a synthetic peptide corresponding to 16 amino acids near the amino-terminus of human BTK. Source/Host Source/Host Rabbit Species Reactivity Species Reactivity Human Conjugate Conjugate Unconjugated Applications Applications immunocytochemistry: suitable Format Format Buffered aqueous solution Size Size 100μg Buffer Buffer Supplied in PBS with 0.02% sodium azide. Storage Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C GENE INFORMATION GENE INFORMATION Gene Name Gene Name BTK Bruton agammaglobulinemia tyrosine kinase [ Homo sapiens (human) ] Official Symbol Official Symbol BTK Synonyms Synonyms BTK; Bruton agammaglobulinemia tyrosine kinase; AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1; tyrosine-protein kinase BTK; B-cell progenitor kinase; agammaglobulinaemia tyrosine kinase; truncated Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK isoform (lacking exon 14); dominant-negative kinase-deficient Brutons tyrosine kinase 45-1 Ramsey Road, Shirley, NY 11967, USA Email: info@creative-diagnostics.com Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved

  2. Entrez Gene ID Entrez Gene ID 695 mRNA Refseq mRNA Refseq NM_000061 Protein Refseq Protein Refseq NP_000052 MIM MIM 300300 UniProt ID UniProt ID Q06187 Pathway Pathway Activated TLR4 signalling; Adaptive Immune System; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; B Cell Receptor Signaling Pathway; B cell receptor signaling pathway; BCR signaling pathway; Class I PI3K signaling events; DAP12 interactions Function Function ATP binding; identical protein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol-3,4,5-trisphosphate binding; protein binding; protein tyrosine kinase activity; protein tyrosine kinase activity 45-1 Ramsey Road, Shirley, NY 11967, USA Email: info@creative-diagnostics.com Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved

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