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Effects of HLA-G Nanoparticles on ILT2 and KIR2DL4 Expression in Cell Cycle Dynamics

This study investigates the impact of HLA-G nanoparticles on the proliferation and cell cycle dynamics of immune cells, focusing on ILT2, ILT4, KIR2DL4, and CD160 expression. By measuring 3H-thymidine incorporation, we assessed DNA content and cell counts at different intervals (6h, 16h, 24h, and 48h) to determine the influence of HLA-G on G0/G1 and G2/M phases. Results reveal significant changes in cell cycle progression and regulation of cyclin D1 in response to HLA-G treatment, highlighting its potential role in modulating immune responses.

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Effects of HLA-G Nanoparticles on ILT2 and KIR2DL4 Expression in Cell Cycle Dynamics

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  1. Supplemental Figure 1 3H-Thymidine incorporation (ΔCPM×10-3) Events ILT2 ILT4 KIR2DL4 CD160 HLA-G Nanoparticles×10-3/ cell Ø Ctrl HLA-G 24h G0/G1 G0/G1 G0/G1 S S S G2/M G2/M Cell counts G2/M DNA content 48h G0/G1 G0/G1 G0/G1 S S S Cell counts G2/M G2/M G2/M DNA content a b c d f e 16h 24h 6h Ctrl HLA-G Cell counts Cyclin D1

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