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Enhancing Translational Research in Pregnancy Trials: Strategies for Success

Explore the concept of translation research in pregnancy trials, transitioning from basic science to clinical through T1 to T2 to T3 phases. Dive into defining the Gestome, assessing gestational age, fetal maturation, and the impact of PTB clinical trials. Learn about trial restrictions, high-risk pregnancy stratification, and efficient design. Discover the importance of phenotyping advocacy, patient engagement, and social media use. Enhance investigator training with cross-training, continuous feedback, entrepreneurial skills, and diverse co-mentoring.

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Enhancing Translational Research in Pregnancy Trials: Strategies for Success

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Presentation Transcript

  1. Breakout Group 1

  2. Concept of Translation Research • Translational research • Transition from basic science to clinical research • T1 to T2 to T3

  3. Key knowledge that we need • Defining the Gestome • What is the normal pregnancy? • Is easy measure of gestational age the primary outcome we should assess or should we assess fetal maturation

  4. PTB clinical trials • Restrictive nature of trials on pregnant women • Stratification of pregnancy to high risk vs non-high risk • Do what we know works – e.g., reducing smoking • Make clinical trials more efficient via better less restrictive design • Better phenotyping

  5. Advocacy • Take a more positive tack on presenting work and translatability • Engage patients • Use social media to improve engagement • Graphic messaging

  6. Training of investigators • Cross training for translational research • Basic to Clinical • Clinical to Basic • Continuous feedback • Train to be entrepreneurial • Co-mentoring for diverse intellectual approaches and shared lexicons

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