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Afferent Input to the Spinal Cord: Insights into Somatosensory System and Pain

This lecture by Prof. Marshall Devor, Ph.D., explores the afferent input mechanisms to the spinal cord, detailing the functions of nociceptors, flexor reflexes, and segmentary responses. It discusses the somatotopic mapping of sensory input through Rexed's laminae, the roles of different types of neurons, and the neurophysiology behind pain perception. Key concepts like collateral branching, divergence, and convergence are examined, along with specific dermatomes and the trigeminal system. Understanding these neural pathways is critical for advancing pain research and therapy.

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Afferent Input to the Spinal Cord: Insights into Somatosensory System and Pain

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  1. 08-9 פיסיולוגיה מורחב Somatosensory System and Pain lecture 4: Afferent input to the spinal cord Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew University of Jerusalem

  2. Collateral branching • flexor reflex • flexor reflex afferents • nociceptors • multisegmental response flexion  extension  nociceptive afferent

  3. flexor reflex segmental reflex

  4. primary sensory neurons

  5. D rostral V caudal somatotopic mapping (note overlapping RFs) rostral cranial cervical thoracic lumbar sacral coccygeal caudal

  6. substantia gelatinosa

  7. A Aδ C Rexed laminae dorsal horn ventral horn

  8. NK1 SP substance P – neurotransmitter/ neuromodulator neurokinin 1 (NK1) SP receptor

  9. somatotopic mapping • Rexed’s laminae • divergence • convergence

  10. dermatome T11 T10 L1 dermatome L4 L6 T10-T11 overlap somatotopic map

  11. opthalmic division maxillary division mandibular division trigeminal system V1,V2,V3 V = 5th cranial nerve caudal trigeminal nucleus = dorsal horn of V

  12. rostral proximal Med. Lat. Lat. caudal distal fore distal rostro-caudal proximo-distal proximal hind somatotopic map

  13. somatosensory mapping succinyl dehydrogenase

  14. somatotopic mapping • Rexed’s laminae • divergence • convergence

  15. some SG neurons are "nociceptive specific" low threshold specific WDR multireceptive BT+ P+ P- Rexed’s laminae X

  16. synaptic input into the dorsal horn

  17. divergence

  18. Divergence SA1

  19. Convergence

  20. Convergence

  21. convergence divergence

  22. פיסיולוגיה מורחב Somatosensory System and Pain lecture 4: Afferent input to the spinal cord Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for Research on Pain Institute of Life Sciences Hebrew University of Jerusalem

  23. Muscle spindle afferent (DRG) Muscle spindle כישור שריר Polysynaptic antagonist muscle (inhibitory interneuron) Monosynaptic agonist muscle simple behavior myotactic (stretch) reflex …demo

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