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Assessment of Locomotor Activity and Rota-Rod Performance in MPTP and MA Treated Mice

This study evaluates the locomotor activity and motor coordination of mice subjected to various dosages of MPTP (15 mg/kg and 20 mg/kg) and MA (5 mg/kg and 7 mg/kg). Using standardized tests, we measured the distance moved over 30 minutes and latency in Rota-Rod performance, comparing saline controls with treated groups. Results demonstrated significant variations in locomotion and motor skills across different treatment groups, highlighting the effects of MPTP and MA on motor function over 3-day, 7-day, and 14-day periods.

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Assessment of Locomotor Activity and Rota-Rod Performance in MPTP and MA Treated Mice

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  1. A. Locomotor activity B. Locomotor activity Saline Saline MPTP 15 mg/kg MA 5 mg/kg MPTP 20 mg/kg MA 7 mg/kg §§ 8000 8000 § && §§ 7000 7000 & && 6000 6000 * * ** ** 5000 5000 *** *** *** *** 4000 4000 Distance moved (cm/30 min) Distance moved (cm/30 min) *** *** 3000 3000 2000 2000 1000 1000 0 0 3d 7d 3d 7d 14d 14d C. Rota-Rod performance D. Rota-Rod performance Saline Saline MA 5 mg/kg MPTP 15 mg/kg MA 7 mg/kg MPTP 20 mg/kg § 300 300 & & 250 250 ** * ** ** 200 200 *** *** *** Latency(second) Latency(second) *** 150 150 100 100 50 50 0 0 3d 7d 3d 7d 14d 14d Supplemental Figure 1.

  2. Dyn+/+ - Saline Dyn-/- - Saline Dyn+/+ - MA (5 mg/kg) Dyn-/- - MA (5 mg/kg) Dyn+/+ - MA (7 mg/kg) Dyn-/- - MA (7 mg/kg) 40 * * * * * * 39 * * * * * * 38 * * * * Rectal temperature 37 36 35 34 basal 1st 2nd 3rd 4th Supplemental Figure 2.

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