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Muscle Tissue Cont. Physiology Chapter 10

Muscle Tissue Cont. Physiology Chapter 10

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Muscle Tissue Cont. Physiology Chapter 10

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  1. Muscle Tissue Cont. Physiology Chapter 10

  2. Contraction of Skeletal Muscle = The Sliding Filament Mechanism • thin and thick filaments slide past each other to shorten each sarcomere and thus each myofibril • the cumulative effect is to shorten the muscle http://www.lab.anhb.uwa.edu.au/mb140/CorePages/Muscle/Muscle.htm#SKELETAL

  3. Skeletal Muscle Innervation The Neuromuscular Junction: • where neurons communicate with the muscle fibers • point of communication is a small gap = synapse • the chemical that travels across the synapse = neurotransmitter (acetylcholine - ACh)

  4. Steps of Skeletal Muscle Contraction 1. Neurotransmitter ACh is released from the neuron; binds to its receptor on the sarcolemma, and causes the sodium channels to open

  5. Steps of Skeletal Muscle Contraction 2. As Na+ ions flow in, an action potential begins action potential = the spread of depolarization 3. ACh removed by enzyme acetylcholinesterase

  6. Steps of Skeletal Muscle Contraction 4. Action potential causes release of Ca++ ions 5. Ca++ binds to troponin, causing tropomyosin to move out of its blocking position 6. Contraction: myosin forms cross bridges to actin, muscle shortens, ATP is used

  7. Steps of Skeletal Muscle Contraction 7. Ca++ ions are reabsorbed 8. Myosin binds to new ATP 9. Troponin-tropomyosin complex returns to normal position 10. Contraction ends; muscle returns to its resting length STUDY FIG. 10.11 p. 317

  8. Skeletal Muscle Contraction = Sliding Filament Theory

  9. The Contraction Cycle Animation http://www.sci.sdsu.edu/movies/actin_myosin_gif.html

  10. Rigor Mortis • When death occurs, Ca++ ions leak and cause some contraction of the muscles = stiffness • Without ATP, cross-bridges cannot detach • Lasts ~24 hours, then lysosomal enzymes break down myofilaments

  11. To help you memorize muscles, check out: • http://msjensen.education.umn.edu/webanatomy/ University of Minnesota, WebAnatomy • With your laptop, check out: www.gwc.maricopa.edu/class/bio201/muscle/mustut.htm