G3 Workshop North America Leadership Conference March 3, 2006 This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex is prohibited.
Mark R. Bartlett Ph.D. Sr. Director, Pharmanex New Product Development
MSNBC.com Spartan diet may slow agingNIH launches study to test practicality By Rob Stein The Washington Post As the rest of the nation has been supersizing, a small cadre of Americans such as Francesca Skelton have been radically downsizing their diets — not to slim down their physiques but to slow down the hands of time. Skelton is an adherent to the theory that "caloric restriction" can hold back the aging process by fundamentally altering basic metabolic functions in ways that protect the body from decaying as quickly. So for years, the District grandmother and others like her have been eating often radical diets carefully calibrated to slash calories they consume each day while still providing their bodies with the nutrients they need.
Green Tea and Longevity Green Tea Consumption (Cups/Day) Prospective, 11-year cohort study of 8,552 subjects in Yoshimi, Japan, 1986-1997. From: H. Fujiki et al., Ann. N.Y.Acad.Sci., 928:274, 2001; used with author’s permission
Aging Symptoms Antioxidants Addresses the Root Cause of Aging: DNA Damage • DNA (DeoxyriboNucleic Acid) is your genetic blueprint • DNA enables healthy cell renewal into old age
Most Vulnerable to free radicals… Cell Membrane DNA
Free Radical Sources • Environmental pollution (smog, ozone, NO2) • Radiation exposure: • sunlight (UV-light), X-rays, etc. • Smoking: • 10,000,000,000,000,000 free radicals/cigarette! • Eating and Breathing: metabolism in your mitochondria
SOD CAT Mitochondria – The Energy Furnaces of the body Free Radicals
MSNBC.com • Starve Your Way to HealthIt works for mice and fruit flies, but can ultra-low-calorie diets extend the life of humans? • By Jerry Adler and Anne Underwood • Newsweek • Jan. 19 issue - If the world is divided into people who live to eat and those who eat to live, perhaps there ought to be a third category for Brian Delaney. At 5 feet 11 inches and 139 pounds, Delaney, 40, is really, really thin. Thin, and hungry. He limits his calories to 1,800 a day, in part by eating just two meals, except when he has a dinner date, in which case that's the only meal he eats. After 10 years on this regimen—actually, he started out at 1,400 calories a day, less than half of what the average American male consumes—he still experiences "the same pit in my stomach" every afternoon, but now finds it "easier to deal with." Especially when he thinks of all the diseases he's avoiding. If Brian Delaney is right, he may well have the last laugh on the rest of humanity ... sometime in the 22d century.
Aging so far… • DNA damage • Cell membrane damage • Uncontrolled free radical leakage from Mitochondria The most common link?Free Radicals
Antioxidant Health Benefits Journal of the American Medical Association “… low levels of the antioxidant vitamins (vitamins A, E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone.” “It appears prudent for all adults to take vitamin supplements.” Robert H. Fletcher, MD, MSc; Kathleen M. Fairfield, MD, DrPH, Harvard UniversityJournal of the American Medical Association 2002; 287: 3127-3129
3 years ago…Pharmanex began Searching the World for Superfruits • R&D evaluated hundreds of fruits for… • Extraordinary antioxidant power • Measurable (Scanner) • Protect cells, (DNA, Membranes) • Enhance internal antioxidant production
Fruit Phytonutrients • At least 1,000 phytochemicals identified with cell protective effects • Very few (25) studied • Fruits and vegetables – more than meets the eye • We don’t eat enough fruits and vegetables
Families of Antioxidants • Vitamin E: 8 natural forms
Families of Antioxidants • Vitamin E: 8 natural forms • Vitamin C:
Families of Antioxidants • Vitamin E: 8 natural forms • Vitamin C • (Metallo-enzyme cofactors) • Selenium, Zinc, Manganese, Copper Zinc Enzyme Protein
Families of Antioxidants • Vitamin E: 8 natural forms • Vitamin C: 500 mg • (Metallo-enzyme cofactors) • Selenium, Zinc, Manganese • Flavonoids: • Catechins, • polyphenols etc
Families of Antioxidants • Vitamin E: 8 natural forms • Vitamin C • (Metallo-enzyme cofactors) • Selenium, Zinc, Manganese • Flavonoids: • Catechins, polyphenols etc • Carotenoids: • Β-carotene, lutein, lycopene, α-carotene
Your Antioxidant Network More than just One… • Vitamin E: 8 natural forms • Vitamin C • Metallo-enzymes (cofactors) • SOD, Catalase, Glutathione per. • Selenium, Zn, Mn, Cu • Flavonoids: • Catechins, polyphenols etc • Carotenoids: • Β-carotene, lutein, lycopene, α-carotene
Pharmanex Research Centerswere involved… • Provo R&D Center • Shanghai R&D Center • Beijing R&D Center
years of searching • Almost all failed Selection criteria • All but Four (g+3) very special fruits
3Pharmanex Research Centers 3 Years of Searching and R&D • Gâc fruit (Chinese Bitter Cucumber) • Chinese Lycium (Wolfberry) • Cili fruit • Siberian Pineapple (Seabuckthorn) 3 +1 Superfruits
Gâc -“Fruit From Heaven” • Indigenous to Southern Asia Bangladesh, Burma, Cambodia, China, India, Japan, Laos, Malaysia, Philippines, Thailand, and Vietnam • Traditionally used internally and externally* Topical: wound healing Internally: eye health, and to promote growth in children* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Antioxidants in Gâc Pulp • Extraordinarily rich in antioxidants, esp. lycopene, beta-carotene, vitamin E • Unique fatty acids → Lipocarotenes™ Pulp (aril) Fruit flesh (mesocarp) Seeds
Gac Fruit Lycopene Content 70 x more than tomatoes! mcg/g wet weight Ishida et al., J Agric Food Chem 52:274, 2004
Gac Fruit Beta-CaroteneContent 10 x more than carrots! mcg/g wet weight Ishida et al., J Agric Food Chem 52:274, 2004
Zeaxanthin in Chinese Lycium Fruit 40 x more than yellow corn! mcg/g wet weight
Vitamin C in Cili Fruit 60 x more than oranges! mg/100g wet weight
Vitamin C Vitamin E Antioxidant protection
Carotenoid protection Betacarotene
Betacarotene Lutein Carotenoid protection
UVA UVB Visible Carotenoid protection Betacarotene Lutein Lycopene
Betacarotene Vitamin C Lutein Lycopene Vitamin E Antioxidant protection
Carotenoids • First line of defense antioxidants* • Protect cell membranes* • Protect DNA* • Enhance communication in cell membranes* • Found in a diet rich in fruits and vegetables • Indicator of overall antioxidant health* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Carotenoids Predict Antioxidant Status • Recent paper published in the Journal of Nutrition • Carotenoids (blood) are indicator of total antioxidant status • Carotenoids interact with the antioxidant network • Vitamin E (blood) is not a good indicator of antioxidant status
Carotenoid molecules shift blue laser light color to green: from 473 nm to 510 nm Raman Spectroscopy Intense monochromatic light (one color only) interacts with molecules that have vibrational energy (e.g., carotenoids) and gets scattered at a higher wavelength (color). Sir C. V. Raman, Nobel Prize in Physics, 1930
Pharmanex BioPhotonic Scanner • Measures skin carotenoids –an indication of your personal antioxidant protection • Easy & non-invasive • Scientifically and clinically validated • Gold standard Measure antioxidant effect of g3 in your own body!
1.10 tomato juice 1.00 0.90 Relative risk tomato fruits 0.80 pizza 0.70 tomato sauce 0.60 0 1 2 3 Servings Bioavailability Effect of tomato food products on prostate health risk from Giovanucci et al. J. of Natl. Canc. Inst. 87, 1767 (1995)
50,000 1 40,000 2 3 4 Antioxidant Network Score 5 30,000 6 7 8 9 10 20,000 11 10,000 Week 0 Week 8 g3Increased Antioxidant Network Scores ~9,500 in 8 Weeks
Noni & Xango vs. g3 10,000 Tahitian Noni XanGo 8,000 6,000 Antioxidant Score 4,000 2,000 0 Week 0 Week 2 Week 4 Week 6 Week 8
Other Ingredients Chinese Lycium (Wolfberry; Lycium chinense) 2000 years TCM history in China • Longevity, wellness, vision • Cellular rejuvenation:* protects DNA* • antioxidant (SOD, GPX) Cili Fruit (Rosa roxburghii) • Cardiovascular, antioxidant benefits:* • ↓ oxLDL, increases SOD* • Addresses symptoms of Aging* *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is Catalytically Active g3 activates SOD and Catalase* • the body's catalytic antioxidant system • antioxidant protection inside the cell, where it is needed the most SOD: Superoxide Dismutase • most important antioxidant enzyme • requires copper, zinc & manganese (LifePak) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Betacarotene Lutein Vitamin C Lycopene Vitamin E Vulnerable to Oxidation
SOD Catalase Vitamin E SOD CAT Internal Antioxidants
The Measurable Difference You have the 3 most powerful tools of the entire nutritional supplement industry worldwide: • lifepak nano: The best multi-nutrient supplement. • : The best functional fruit juice. • BioPhotonic SCANNER: The best consumer test for antioxidant nutrition.
Key Business Takeaways • G3™ supports your body’s antioxidant network* • Lipocarotenes™ naturally increase absorption of antioxidants* • SCS Certified ~ 9,500 increase in 8 weeks • 6 times more powerful than Noni or Xango™* • Proprietary and patent pending *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.