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Exploring gene regulation during cerebellar development

The Jasons Project 2 focuses on predicting co-regulated genes by analyzing multiple expression patterns from various data sources, including GeneChip, RT-PCR, and custom arrays. The project utilizes the Cerebellar Development Transcriptome Database to study gene expression in the cerebellum, a key brain region for motor control. By examining genes such as Reelin, Grid2, and Kcnj6, the initiative seeks to uncover relationships between gene expression and human neural disorders. The goals include comparing expression methods, identifying co-regulated genes, and exploring their implications for conditions like ataxia and autism.

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Exploring gene regulation during cerebellar development

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  1. The Jasons Project 2: Predicting co-regulated genes by comparison of multiple expression patterns Background/Introduction Organization of the Database (from GeneChip, RT-PCR, custom arrays, ISH) - Robust Temporal and Spatial Expression- Gene Ontology and Neuroanatomical classification Gene search utility to compare many genes- Example: Reln, Rora, Kcnj6, Grid2 The cerebellum is the region of the brain that coordinates motor control, and many human neural disorders impact the cerebellum. Several spontaneous mouse mutants with motor defects have been found, including: staggerer, reeler, weaver, and lurcher. This problem space encourages exploration of gene expression levels and patterns in the cerebellum using the Cerebellar Development Transcriptome Database. Exploring gene regulation during cerebellar development Reelin (reeler) Grid2 (weaver) Kcnj6 (Lurcher) RORa (staggerer) Potential Expansions of the Problem Space Project 1: Comparison of methods for studying gene expression • Disease relevancy • Autism candidate genes • RORa • Reelin • Ataxia • Transcriptional Regulation • Transcription Factors • RORa • Co-regulation of genes of similar function? RORa (staggerer) Goals and Aims The richness of this database allows exploration of many aspects of gene expression studies, for example: • Relating temporal and spatial patterns of expression • Comparing different methods for measuring gene expression • Finding relationships between genes with similar behavioral disorders • Discovery of genes that may be co-regulated Tools Cerebellar anatomy and function- Anatomical layers of the cerebellum- Allan Brain Atlas, Gene Paint, BGEMGene ontology - clustered by function Kcnj6 (weaver)

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