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LUNG TRANSPLANTATION

Explore lung transplantation data from 1985 to 2003, including procedure types, recipient demographics, survival rates by era, diagnosis comparisons, and risk factors for mortality. Analyze the impact of age, gender, diagnosis, and procedure type on outcomes.

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LUNG TRANSPLANTATION

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  1. LUNG TRANSPLANTATION Overall

  2. 1655 1563 1497 1443 1436 1412 1365 1370 1229 1086 922 706 418 188 83 15 46 13 NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE

  3. AVERAGE CENTER VOLUMELung Transplants: January 1, 1998 - June 30,2003

  4. DISTRIBUTION OF TRANSPLANTS BY CENTER VOLUMELung Transplants: January 1, 1998 - June 30,2003

  5. LUNG TRANSPLANTS:Donor Age by Year of Transplant

  6. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS(1/1985-6/2003)

  7. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS BY ERA

  8. LUNG TRANSPLANTATIONKaplan-Meier Survival (Transplants: January 1990 - June 2002)

  9. LUNG TRANSPLANTATION Adult Recipients

  10. ADULT LUNG TRANSPLANTATION: Indications(1/1995-6/2003)

  11. ADULT LUNG TRANSPLANTATION: Indications(Transplants: January 1995 - June 2003) Single Lung Transplants Bilateral/Double Lung Transplants

  12. ADULT LUNG TRANSPLANTATIONIndications By Year (%)

  13. ADULT LUNG TRANSPLANTATIONIndications By Year (Number)

  14. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Era (Transplants: January 1988 – June 2002) Survival comparisons by era 1988-92 vs. 1993-97: p = 0.0004 1988-92 vs. 1998-2002: p < 0.0001 1993-97 vs. 1998-2002: p = 0.0001

  15. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Age Group(Transplants: January 1990 – June 2002)

  16. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Gender(Transplants: January 1990 – June 2002)

  17. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1990 – June 2002) Survival comparisons Alpha-1 vs. IPF: p < 0.0001 Alpha-1 vs. PPH: p = 0.0009 CF vs. COPD: p = 0.0001 CF vs. IPF: p < 0.0001 CF vs. PPH: p < 0.0001 CF vs. Sarcoidosis: p = 0.0014

  18. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 3 Months(Transplants: January 1990 – June 2002) Survival comparisons Alpha-1 vs. IPF: p < 0.0001 Alpha-1 vs. COPD: p = 0.002 CF vs. COPD: p < 0.0001 CF vs. IPF: p < 0.0001 PPH vs. COPD: p < 0.0001 PPH vs. IPF: p < 0.0001 COPD vs. IPF: p = 0.002

  19. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year(Transplants: January 1990 – June 2002) Survival comparisons Alpha-1 vs. IPF: p = 0.0002 Alpha-1 vs. COPD: p < 0.0001 CF vs. COPD: p < 0.0001 CF vs. IPF: p < 0.0001 PPH vs. COPD: p < 0.0001 PPH vs. IPF: p < 0.0001

  20. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1990 – June 2002)

  21. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 3 Months(Transplants: January 1990 – June 2002)

  22. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year(Transplants: January 1990 – June 2002)

  23. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival for Eisenmenger’s Syndrome(Transplants: January 1990 – June 2002)

  24. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival By Procedure Type (Transplants: January 1990 – June 2002)Diagnosis: Alpha-1 Antitrypsin Deficiency P = 0.02

  25. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 – June 2002) Diagnosis: Emphysema/COPD P < 0.0001

  26. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 – June 2002)Diagnosis: IPF P = 0.5

  27. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type (Transplants: January 1990 – June 2002)Diagnosis: PPH P = 0.3

  28. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2002) Diagnosis: Emphysema/COPD, Single Lung

  29. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2002) Diagnosis: Emphysema/COPD, Double/Bilateral Lung

  30. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2002) Diagnosis: IPF, Single Lung

  31. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Procedure Type and Era(Transplants: January 1990 – June 2002) Diagnosis: IPF, Double/Bilateral Lung

  32. ADULT LUNG TRANSPLANTATIONKaplan-Meier Survival by Donor CMV status/Recipient CMV status(Transplants: October 1999 – June 2002)

  33. ADULT LUNG TRANSPLANTS (1995-6/2002)Risk Factors for 1 Year Mortality (N=8,043)

  34. ADULT LUNG TRANSPLANTS (1995-6/2002)Risk Factors for 1 Year Mortality (N=8,043)

  35. ADULT LUNG TRANSPLANTS (1995-6/2002)Risk Factors for 1 Year Mortality (N=8,043)

  36. ADULT LUNG TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality

  37. ADULT LUNG TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient Age

  38. ADULT LUNG TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityCenter volume

  39. ADULT LUNG TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient Pulmonary Vascular Resistance (PVR)

  40. ADULT LUNG TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year Mortality FEV1 (% predicted) in Recipients with IPF

  41. ADULT LUNG TRANSPLANTS(1/1995-6/2002)Risk Factors for 1 Year MortalityRecipient Bilirubin

  42. ADULT LUNG TRANSPLANTS (1995-6/2002)Factors Not Significant for 1 Year Mortality Recipient factors: pCO2, chronic steroid use, transfusions, recent infection requiring IV drug therapy Donor factors: Clinical infection, history of hypertension, history of cancer Transplant factors: Procedure type, ABO compatibility, HLA mismatch, year of transplant, height ratio

  43. ADULT LUNG TRANSPLANTS (1995-6/1998)Risk Factors for 5 Year Mortality (N=4,178)

  44. ADULT LUNG TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year Mortality

  45. ADULT LUNG TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityRecipient Age

  46. ADULT LUNG TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityDonor Age

  47. ADULT LUNG TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityDonor weight

  48. ADULT LUNG TRANSPLANTS(1/1995-6/1998)Risk Factors for 5 Year MortalityRecipient Pulmonary Vascular Resistance (PVR)

  49. ADULT LUNG TRANSPLANTS (1995-6/1998)Factors Not Significant for 5 Year Mortality Recipient factors: Hospitalized, chronic steroid use, transfusions, history of malignancy, PRA, gender, FVC, FEV1, height, weight Donor factors: Gender, clinical infection, history of hypertension, history of cancer, history of diabetes, height Transplant factors: Procedure type, ABO compatibility

  50. ADULT LUNG TRANSPLANTS (1995-6/1998)Risk Factors for 5 Year MortalityConditional on Survival to 1 Year (N=2,982)

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