Rev3-Dependent Mutations and Somatic Hypermutation in Immunoglobulin Gene Diversification

Dec 06, 2025

200 likes | 307 Vues

This study explores the role of Rev3-dependent mutations in double-strand break (DSB) repair and their association with somatic hypermutation in immunoglobulin genes. The induction of hypermutation relies on DNA polymerase iota, highlighting a crucial mechanism for antibody diversification. The findings suggest that AID mutates E. coli, indicating that DNA deamination may underlie the diversification process. These insights contribute to our understanding of immune responses and the molecular mechanisms regulating genetic variability within immune cells.

gigi

Télécharger la présentation

Rev3-Dependent Mutations and Somatic Hypermutation in Immunoglobulin Gene Diversification

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

trp1-1 Rev3-dependent mutations associated with DSB repair Strathern

Rag1/Rag2

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota AHMAD FAILI*, SAID AOUFOUCHI*, ERIC FLATTER*, QUENTIN GUÉRANGER, CLAUDE-AGNÈS REYNAUD & JEAN-CLAUDE WEILL

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification SVEND K. PETERSEN-MAHRT*, REUBEN S. HARRIS* & MICHAEL S. NEUBERGER