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brainstorm-cell

Adult stem cell therapy for neurodegenerative diseases. www.brainstorm-cell.com. BrainStorm Cell Therapeutics Inc. (OTCBB:  BCLI). www.brainstorm-cell.com. BrainStorm is a leading developer of stem cell technologies to provide treatments for currently incurable neurodegenerative diseases.

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brainstorm-cell

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  1. Adult stem cell therapy for neurodegenerative diseases www.brainstorm-cell.com

  2. BrainStorm Cell Therapeutics Inc. (OTCBB:  BCLI) www.brainstorm-cell.com BrainStorm is a leading developer of stem cell technologies to provide treatments for currently incurable neurodegenerative diseases. The Company is focused on developing NTF cells from the patient's own bone marrow in order to treat, Parkinson, ALS, and Spinal Cord Injury.

  3. Parkinson Disease PDis a degenerative disorder of the central nervous system (loss of dopamine-containing nerve cells) that often impairs the sufferer's motor skills, speech and other functions. 3 • Large and growing population of Parkinson Disease patients (4 M in the Western world). • Heavy social burden (according to NINDS, $26B in the U.S. annually). • Disease anatomy and pathology is well known, although causes are still obscure. • Affects a clearly defined region of the brain, the substantia nigra.

  4. Amyotrophic Lateral Sclerosis Disease ALS (sometimes called Lou Gehrig's disease) is a progressive, usually fatal, neurodegenerative disease caused by the degeneration of motor neurons, the nerve cells in the central nervous system that control voluntary muscle movement. 4 • 5,600 people in the U.S. are diagnosed with ALS Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) each year. Total 30,000 patients in the US. & 100,000 around the world. • Fatal progressive loss of motor neurons in brain and spinal cord. • Leads to gradual loss of movement ability, culminating in death. • One approved drug – Rilutek (Riluzole) affords only an additional few months of life. • Pressing need for new effective therapies.

  5. Cell technologies may offer a major improvement over medication, as they target the diseased cell or organ and replace it with a healthy alternative. Advantage of Cell Therapy

  6. Adult Stem Cells Adult stem cells are undifferentiated cells, found throughout the body after embryonic development, that multiply by cell division to replenish dying cells and regenerate damaged tissues. Adult Stem Cells (From Bone Marrow) • Advantages: • Non tumor forming. • More than 40 years safety record. • Harvested from patient – therapy does not require immunosupression. • Unlike embryonic stem cells, the use of adult stem cells in research and therapy is not considered to be controversial as they are derived from adult tissue samples rather than human embryos.

  7. Brainstorm’s strategy NurOwn™ Therapeutic Technology Autologous Bone Marrow-derived Stem Cell Therapy BrainStorm Patent Into neurotrophic factors (NTF) secreting cell BrainStorm know-how Bone marrow aspiration www.brainstorm-cell.com

  8. Intellectual Property • Trademark filed for NurOwnTM in the US • 3 Patents pending Bone Marrow Stem Cells • PCT covering methods of generating Dopamine-producing neural cells from bone marrow stem cells; Currently in national phase (Patent granted in Singapore) PCT covering methods of generating oligodendrocytes from bone marrow stem cells; Currently in national phase Neuron Oligodendrocyte NTF cells 3. PCT covering methods of generating GDNF-producing cells from bone marrow stem cells; Currently in national phase www.brainstorm-cell.com

  9. Medical Center Hematology: Bone Marrow aspirate NurOwnTM Neurosurgery: NurOwn™ Cells implantation Business Model cGMP Facility Patient population Insurance payment to medical center Medical center purchases BrainStorm cell processing services www.brainstorm-cell.com

  10. BrainStorm Financial Summary Stock Symbol: OTCBB:BCLI Shares outstanding: 55.3M Current price of stock : ~ $0.1 52 week price range: $0.07-$0.76 Market capitalization: ~$5M Approximate Public Float: 17M shares Monthly current burn rate : $150K Seeking for $10M to complete phase I and II clinical trials in ALS and phase I clinical trials in Parkinson. www.brainstorm-cell.com

  11. Safe Harbor Disclaimer www.brainstorm-cell.com 11 This presentation may contain certain ‘forward-looking statements’. All statements, other than statements of historical fact, that address activities, events or developments that we intend, expect, project, believe or anticipate will or may occur in the future are forward-looking statements. Such statements are based upon certain assumptions and assessments made by our management in light of their experience and their perception of historical trends, current conditions, expected future developments and other factors they believe to be appropriate. The forward-looking statements included in this presentation are also subject to a number of material risks and uncertainties. We caution investors not to place undue reliance on the forward-looking statements contained in this presentation. We would advise reading our annual report filed with the United States Securities and Exchange Commission on Form 10-K for a more detailed description of these risks.

  12. www.brainstorm-cell.com

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