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Antigen-presenting cell (APC)

Gene silencing. Antigen-presenting cell (APC). ( 2) Phagosomal escape ・ Proton sponge effect of dendrimer ・ Disruption of phagosome membrane by a -CyD. (1) MR-mediated phagocytosis. ・ Enhancement of recognition ability by MR. Mannose receptor (MR). Phagosome. Lysosome.

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Antigen-presenting cell (APC)

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  1. Gene silencing Antigen-presenting cell (APC) (2) Phagosomal escape ・Proton sponge effect of dendrimer ・Disruption of phagosome membrane by a-CyD (1) MR-mediated phagocytosis ・Enhancement of recognition ability by MR Mannose receptor (MR) Phagosome Lysosome Man-S-a-CDE(G3)/siRNA complex (3)Localization in cytoplasm (4)Dissociation of siRNA : Dendrimer (G3) : a-CyD : Mannose : Spacer : siRNA : RISC (5)Complexation with RISC Supplementary Figure 5. Proposed scheme for APC-selective RNAi efficiency of Man-S-a-CDE (G3, DSM4)/siRNA complex.

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