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Advances in CNS and CSF Flow Models: Systemic Simulations and Methodology Overview

This document outlines the advancements made in the systemic flow modeling of the Central Nervous System (CNS) and Cerebrospinal Fluid (CSF) as of March 3, 2011. Supervised by Cierra M. Hall and guided by Professor Linninger at the University of Illinois, Chicago, the work focuses on revised models for four species and emphasizes the integration of CSF and CNS flow systems. Key aspects include the validation of simulations, adjustments in vascular connections, and plans for ongoing research, culminating in the preparation of a research paper detailing the methodology.

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Advances in CNS and CSF Flow Models: Systemic Simulations and Methodology Overview

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  1. CNS, CSF Flow Models, and Systemic Simulations March 3, 2011 Loren Kim Mentor: Cierra M. Hall Advisor: Professor Linninger Laboratory for Product and Process Design Department of Bioengineering University of Illinois, Chicago, IL

  2. Topics: • Systemic Flow Model Simulations of 4 Species • CNS model *Revisions • CSF model • Connection of the CSF flow model to the CNS model • Connection of the CNS flow model to the systemic flow model

  3. Systemic Flow Model Simulations • Performed and validated simulations for 4 species Hagen Poiseuille's Equation:

  4. Systemic Flow Modeling Simulations

  5. Systemic Flow Model Simulations

  6. CNS model *Revisions • Addition of the right and left brachiocephalic veins • Connection of the Sphenoparietal Sinus • Revisiting the Willis Circle • Removal of unnecessary arteries and veins connecting to the spinal capillaries

  7. CSF Model

  8. Connection of CSF and CNS

  9. Systemic Flow Modeling

  10. Goals: • Finish revising the CNS model • Run simulations on the CNS and CSF model • Connect the models • Start the research paper: Introduction and Methods

  11. Questions?

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