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Modeling Inflammation

Modeling Inflammation. Diana Stefan Awanti Sambarey August 12, 2012 CSHL CCB Final Project Presentation. A healthy inflammatory response. Reduced model of inflammation.

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Modeling Inflammation

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  1. Modeling Inflammation Diana Stefan AwantiSambarey August 12, 2012 CSHL CCB Final Project Presentation

  2. A healthy inflammatory response

  3. Reduced model of inflammation • Kumar, R., Clermont, G., Vodovotz, Y., Chow, C.C., 2004. The dynamics of acute inflammation. J. Theor. Biol. 230, 145–155. l m p p = pathogen m = early pro-inflammatory mediator l = late pro-inflammatory mediator time

  4. Reduced model of inflammation • Kumar, R., Clermont, G., Vodovotz, Y., Chow, C.C., 2004. The dynamics of acute inflammation. J. Theor. Biol. 230, 145–155. l m p p = pathogen m = early pro-inflammatory mediator l = late pro-inflammatory mediator time

  5. Exploring dynamics of the reduced model of inflammation Time course of p, m and l for the healthy response Late inflammatory mediators Persistent non-infectious inflammation

  6. Recurrent infection Persistent infectious inflammation 4 2 0 Severe immune deficiency

  7. Bifurcations Klm decreased FP 5 FP2 Kpm decreased FP 3 FP 4 Kmp decreased Healthy Oscillations Recurrent Infection FP3 FP5 FP1 FP4 FP 5 Persistent NI Inflammation Recurrent Infection Healthy Oscillations FP 3 FP 2 FP 4 Healthy Oscillations FP 3 Recurrent Infection FP 1

  8. Extension of the model to account for anti-inflammatory mediators. Pathogen Early Mediators Late Mediators Anti-inflammatory Mediators

  9. M Recurrent Infection Healthy Oscillations Kpm M Healthy Oscillations Recurrent Infection Kmp

  10. Concluding Remarks • The model examines the effect of the strength of early and late-inflammatory responses, and describes the parameters that govern the clinical outcome. • The addition of anti-inflammatory mediators prevents persistent non-infectious inflammation by regulating late mediators. • The reduced model allows us to understand the general behavior of the system, however the model needs to be expanded to mimic the phenomenon of inflammation more closely.

  11. Thank you!!

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