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cul1 promoter ARF -/-MEFs p53 -/-MEFs. pdgf  r promoter ARF -/-MEFs p53 -/-MEFs. relative activity. relative activity. c-Myc - + + - + + ARF - - + - - +.

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  1. cul1 promoter ARF-/-MEFs p53-/-MEFs pdgfr promoter ARF-/-MEFs p53-/-MEFs relative activity relative activity c-Myc - + + - + + ARF - - + - - + c-Myc - + + - + + ARF - - + - - + ARF- c-Myc- ARF- c-Myc- OHT hrs 0 4 8 0 4 8 0 4 8 0 4 8 0 4 8 0 4 8 Rat1aMycER -ARF +ARF -ARF +ARF -ARF +ARF genes cad eIF4E gadd45 a b c relative expression OHT hrs 0 2 4 8 0 2 4 8 0 2 4 8 0 2 4 8 0 2 4 8 0 2 4 8 0 2 4 8 0 2 4 8 Cell line DKO p53-/- DKO p53-/- DKO p53-/- DKO p53-/- gene cdk4 cul1 gadd45 p15INK4b relative expression

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