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Non-cirrhotic portal hypertension in HIV+ patients

Non-cirrhotic portal hypertension in HIV+ patients. Liver disease burden in HIV. Clinical case. Unexplained liver disease in HIV - Exclusion. NCPH in the Swiss cohort. Liver disease of unknown etiology in HIV patients. Normal portal tract (Masson).

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Non-cirrhotic portal hypertension in HIV+ patients

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  1. Non-cirrhotic portal hypertensionin HIV+ patients

  2. Liver disease burden in HIV

  3. Clinical case

  4. Unexplained liver disease in HIV -Exclusion

  5. NCPH in the Swiss cohort

  6. Liver disease of unknown etiology in HIV patients

  7. Normal portal tract (Masson)

  8. Portal vein showing dense fibrous thickening of the wall, centered by central stenotic lumen (H&E)

  9. Portal tract without portal vein (Masson)

  10. Portal tract depicting small thin walled vessels replacing portal vein (Masson)

  11. Hypothesis“Two-hit” model for unexplained non-cirrhotic portal hypertension in HIV+ patients

  12. A genetic predisposition for NCPH ?

  13. NEAT projectGenetic markers involved in NCPH in HIV patients

  14. Methodology

  15. NEAT genetic study for NCPH

  16. Summary

  17. Caveats

  18. Acknowledgments

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