kaipo
Uploaded by
33 SLIDES
474 VUES
330LIKES

Neural Fate Determination in PNS Neurons: Insights from Abdominal Hemisegment Neurogenesis

DESCRIPTION

This chapter explores the role of proneural genes, such as achaete and scute, in the neurogenesis of PNS neurons within an abdominal hemisegment. It details the formation of sensory organ precursors (SOPs) through lateral inhibition mediated by Notch and Delta signaling, and discusses asymmetric cell division involving Numb and Notch, leading to diverse neuronal fates. The regulation of proneural gene expression and its impact on sensory organ development, including various types of olfactory sensilla, is analyzed, providing a comprehensive view of neural fate during embryonic development.

1 / 33

Download Presentation
Télécharger la présentation

Neural Fate Determination in PNS Neurons: Insights from Abdominal Hemisegment Neurogenesis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Chapter 4 The Emergence of Neural Fate

  2. d l v’ v PNS Neurons in one Abdominal Hemisegment

  3. Neurogenesis Proneural gene expression (achaete, scute) Proneural cluster SOP (sensory organ precursor) Lateral inhibition (Notch, delta) SOP Asymmetric cell division (numb, Notch) pIIb pIIa neuron socket hair sheath

  4. Sensory organs Proneural genes achaete scute + associated MD neurons + associated MD neurons atonal solo-MD neurons amos

  5. Proneural genes encode basic-helix-loop-helix proteins b HLH achaete 93% 63% scute 26~30% 50% atonal 91% 60% amos

  6. Determination of SOP cells

  7. Regulation of proneural genes

  8. The development of olfactory sensilla coeloconica atonal trichodea amos basiconica From Goulding et al (2000)

  9. Neurogenesis Proneural gene expression (achaete, scute) Proneural cluster SOP (sensory organ precursor) Lateral inhibition (Notch, delta) SOP Asymmetric cell division (numb, Notch) pIIb pIIa neuron socket hair sheath

  10. Neurogenic mutants mutants Wild type

  11. Notch signalinig Delta Notch Su(H) E(spl) E(spl) achaete, scute

  12. Notch signaling pathway leads to downregulation of proneural genes

  13. ES organ SOP hair IIA IIB socket g sheath neuron so h sh n glia Asymmetric Cell Division

  14. Notch SOP Numb Asymmetric localization IIA IIB Numb Cell fate determination

  15. Apical Insc organizer Dlg Lgl Spindle orientation Staufan Prospero mRNA Pon Numb Miranda Prospero Basal

More Related
SlideServe
Audio
Live Player
Audio Wave
Play slide audio to activate visualizer
Slide 1

Sea Ice

Slide Player

AI NARRATOR Slide 1 of 12

Sea Ice

0:00 0:15