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Differential Gene Expression Analysis in Colorectal and Head/Neck Cancer Using Oligonucleotide Arrays

This research examines transcriptional gene expression profiles in colorectal adenomas, adenocarcinomas, and normal tissues utilizing oligonucleotide arrays. The study emphasizes the importance of identifying differentially expressed genes through multiple statistical methods such as unpaired and paired t-tests, Fisher's method, SAM, and Wilcoxon rank-sum tests. The findings contribute significantly to understanding cancer progression and potential therapeutic targets, enhancing diagnostic and prognostic capabilities in oncology.

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Differential Gene Expression Analysis in Colorectal and Head/Neck Cancer Using Oligonucleotide Arrays

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  1. Reference: [DS1] D.A. Notterman, U. Alon, A.J. Sierk, and A.J. Levine (2001). Transcriptional Gene Expression Profiles of Colorectal Adenoma, Adenocarcinoma, and Normal Tissue Examined by Oligonucleotide Arrays, Cancer Research, 61, 3124–3130.

  2. Reference: [DS2] M. A. Kuriakese et al; Selection and validation of differentially expressed genes in head and neck cancer, manuscript.

  3. Nine Methods to Identify Informative Genes • unpaired t-test (A) • paried t-test (B) • Fisher (C) • Golub (D) • SAM (E) • TNOM (F) • Wilcoxon rank sum test (G) • Park (H) • WEPO (I)

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