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Proteomics LIMS

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Proteomics LIMS. Importance of Infrastructure. Abel Wolman and Linn Enslow perfect the Chlorination of Drinking Water. In one year, the death rate from typhoid dropped over 90% in the United States. LIMS. caLIMS Large LIMS built around Java RMI Inventory Control, Storage Location

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Proteomics LIMS

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  1. ProteomicsLIMS Fox Chase Cancer Center

  2. Importance of Infrastructure Abel Wolman and Linn Enslow perfect the Chlorination of Drinking Water In one year, the death rate from typhoid dropped over 90% in the United States Fox Chase Cancer Center

  3. LIMS • caLIMS • Large LIMS built around Java RMI • Inventory Control, Storage Location • Domain Specific Information • Need to add tables • Don’t want to mangle caLIMS structure Fox Chase Cancer Center

  4. Sample Data Flow Fox Chase Cancer Center

  5. Presentation Tier Business Tier Data Tier caLIMS + protLIMS tables Database protLIMS Struts framework (Servlets, JSP pages, HTML, XML) RMI JDBC caLIMS Logic Objects + protLIMSLogic Objects (Projects, samples, adapters etc) protLIMS EJB Data/File Access Objects Flat files FTP Proteomics LIMS Fox Chase Cancer Center

  6. Added Tables Fox Chase Cancer Center

  7. Prototype Interface Fox Chase Cancer Center

  8. Fox Chase Cancer Center

  9. Fox Chase Cancer Center

  10. ProtLIMS keeps all caLIMS architectural features: N-Tiered structure Extensibility OS Portability Compatibility with other caLIMS systems ProtLIMS uses all major caLIMS technologies: Java Programming Language Java Server Pages, Java Servlets LDAP – Lightweight Directory Access Protocol Java RMI – Remote Method Invocation JDBC – Java Database Connectivity ProtLIMS also uses following technologies: Struts framework J2EE architecture approcah Design Principles Fox Chase Cancer Center

  11. FGDP • Automated, multiple, simultaneous analyses of functional genomics data • Java based using RMI for distribution • Integrated through JDBC to microarray LIMS • Plan to use for QA/QC as well as data analysis for Proteomics LIMS Fox Chase Cancer Center

  12. Models Data Flow Parsing/Image Analysis Normalization Statistical Analysis Filtering Pattern Recognition Image Generation Output Parsing Fox Chase Cancer Center

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