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Muscle and the Sliding filament theory

Muscle and the Sliding filament theory. Myoblasts one nucleus each lacking myofibrils. Myotubes develop myofibrils Many nuclei. FUSE. Skeletal muscle development. Skeletal and Cardiac Muscle. Both demonstrate “striations” or stripes when seen with a microscope

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Muscle and the Sliding filament theory

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  1. Muscle and the Sliding filament theory

  2. Myoblasts one nucleus each lacking myofibrils Myotubes develop myofibrils Many nuclei FUSE Skeletal muscle development

  3. Skeletal and Cardiac Muscle • Both demonstrate “striations” or stripes when seen with a microscope • These stripes represent the regular arrangement of actin and myosin

  4. Myosin is a thick protein and looks dark in the section • Actin is a very small protein and looks pale in the section. The dark ovals are the nuclei of the muscle cells. There may be up to A 100 nuclei per cell

  5. Sarcomeres • Functional contractile unit of striated muscle • 2-3 mm in length • Striations • Made up of regular overlapping pattern • of actin (thin filaments) • myosin (thick filaments) • Delineated by Z lines • Center line is I band

  6. Very close image of muscle A band: myosin I band: actin Z lines: where the actin attaches and the end of a sarcomere

  7. Muscle contraction • When muscle contracts, • all of the actin • (white in the picture, red in the diagram) • will slide over • the myosin • (black in the picture, green in the diagram). • The Z discs will come closer • All of these millions of shortenings in one muslce will result in muscle contractions

  8. Sliding filament mechanism • Sarcomeres shortened • Thin filaments slide over thick filament • Requires ATP • The cells source of energy • other proteins and calcium

  9. Animation of sliding filament • http://3dotstudio.com/zz.html

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