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SLIDING FILAMENT MECHANISM

SLIDING FILAMENT MECHANISM. Anis A. Makky, drg, MKes. Oral Biology Dept. - Dentistry Faculty Airlangga University Surabaya, May 07, 2009. MUSCLE. skeletal muscle smooth muscle cardiac muscle. SKELETAL MUSCLE. muscle fibers contractile protein no extracellular calcium.

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SLIDING FILAMENT MECHANISM

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  1. SLIDING FILAMENT MECHANISM Anis A. Makky, drg, MKes Oral Biology Dept. - Dentistry Faculty Airlangga University Surabaya, May 07, 2009

  2. MUSCLE • skeletal muscle • smooth muscle • cardiac muscle

  3. SKELETAL MUSCLE • muscle fibers • contractile protein • no extracellular calcium

  4. CONTRACTILE PROTEIN • actin : actin troponin I, C, T tropomyosin • myosin • titin • nebulin

  5. SLIDING FILAMENT MECHANISM

  6. Figure 12-11a: Excitation-contraction coupling

  7. Figure 12-11b: Excitation-contraction coupling

  8. Cross-Bridge Formation in Muscle Contraction

  9. Receptors in Muscle • Muscle spindle • Detect dynamic and static changes in muscle length • Stretch reflex • Stretch on muscle causes reflex contraction • Golgi tendon organ (GTO) • Monitor tension developed in muscle • Prevents damage during excessive force generation • Stimulation results in reflex relaxation of muscle

  10. Muscle Spindle

  11. Golgi Tendon Organ

  12. Muscle Fatigue: Causes not well known • Central • "Feeling" • Lactic acid • Peripheral • Glycogen depletion • Ca2+ interference • High Pi levels • ECF high K+ • ACh depletion Figure 12-14: Locations and possible causes of muscle fatigue

  13. THANK YOU

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